Trial | Jadad score | Inclusion criteria | method of PEEP selection | Number of Patients (HP/LP) | Age (HP/LP) | PEEP (cmH2O) (HP/LP) | Gender (HP vs. LP) [male/female] | PaO2/FIO2 (mmHg) (HP/LP) |
---|---|---|---|---|---|---|---|---|
Amato/1998 [12] | 3 | Lung injury score ≥ 2.5 | HPa:LIPc + 2 cmH2O LPb:FiO2-PEEP | 29/ 24 | 36/33 | 13.2 ± 0.4/9.3 ± 0.5 | – | 112/134 |
Ranieri/1999 [13] | 3 | PaO2:FIO2 ≤ 200 mmHg | HPa:LIPc + 2 cm H2O LPb:FiO2-PEEP | 18/19 | 51/49 | 14.8 ± 2.7/6.5 ± 1.7 | 7/11 vs. 10/19 | 149/142 |
Brower/2004 [3] | 4 | PaO2:FIO2 ≤ 300 mmHg | HPa:FiO2-PEEP (ARDSnet) LPb:FiO2-PEEP (PEEP more than 12 cmH2O) | 276/273 | 54/49 | 14.7 ± 3.5/8.9 ± 3.5 | 145/128 vs.157/119 | 151/165 |
Villar/2006 [14] | 3 | PaO2:FIO2 ≤ 200 mmHg | HPa:LIPc + 2 cmH2O LPb:FiO2-PEEP | 50/45 | 48/52 | 14.1 ± 2.8/9.0 ± 2.7 | 23/27 vs.27/18 | 111/109 |
Meade/2008 [5] | 4 | PaO2:FIO2 ≤ 250 mmHg | FiO2-PEEP | 475/508 | 54.5/56.9 | 15.6 ± 3.9/10.1 ± 3.0 | 282/193 vs. 307/201 | 144.8/144.6 |
Mercat/2008 [15] | 4 | PaO2:FIO2 ≤ 300 mmHg | HPa:Pplat LPb: FiO2-PEEP | 385/382 | 60/60 | 14.6 ± 3.2/7.1 ± 1.8 | 260/125 vs. 256/126 | 144/143 |
Talmor/2008 [16] | 3 | PaO2:FIO2 ≤ 200 mmHg | HPa:Transpulmonary pressure LPb:FiO2-PEEP | 30/31 | 54.5/51.2 | 17 ± 6.0/10 ± 4.0 | 19/11 vs. 17/14 | 91/107 |
Huh/2009 [17] | 3 | PaO2:FIO2 ≤ 200 mmHg | HPa:saturation decrease more than 2% and drop of static compliance LPb:FiO2-PEEP | 30/27 | 55/62 |  | 18/12 vs. 17/10 | 115/110 |
ART/2017 [8] | 3 | PaO2:FIO2 ≤ 200 mmHg | HPa: Maximum alveolar recruitment by compliance + 2 cmH2O LPb: FiO2-PEEP | 501/509 | 51.3/56 | 16.8 ± 3.8/13.0 ± 0.3 | 313/188 vs. 318/191 | 119.5/117.2 |