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Table 1 Characteristics of the included patients

From: Higher PEEP improves outcomes in ARDS patients with clinically objective positive oxygenation response to PEEP: a systematic review and meta-analysis

Trial

Jadad score

Inclusion criteria

method of PEEP selection

Number of Patients

(HP/LP)

Age

(HP/LP)

PEEP

(cmH2O)

(HP/LP)

Gender

(HP vs. LP)

[male/female]

PaO2/FIO2

(mmHg)

(HP/LP)

Amato/1998 [12]

3

Lung injury score ≥ 2.5

HPa:LIPc + 2 cmH2O

LPb:FiO2-PEEP

29/ 24

36/33

13.2 ± 0.4/9.3 ± 0.5

–

112/134

Ranieri/1999 [13]

3

PaO2:FIO2 ≤ 200 mmHg

HPa:LIPc + 2 cm H2O

LPb:FiO2-PEEP

18/19

51/49

14.8 ± 2.7/6.5 ± 1.7

7/11 vs. 10/19

149/142

Brower/2004 [3]

4

PaO2:FIO2 ≤ 300 mmHg

HPa:FiO2-PEEP (ARDSnet)

LPb:FiO2-PEEP (PEEP more than 12 cmH2O)

276/273

54/49

14.7 ± 3.5/8.9 ± 3.5

145/128 vs.157/119

151/165

Villar/2006 [14]

3

PaO2:FIO2 ≤ 200 mmHg

HPa:LIPc + 2 cmH2O

LPb:FiO2-PEEP

50/45

48/52

14.1 ± 2.8/9.0 ± 2.7

23/27 vs.27/18

111/109

Meade/2008 [5]

4

PaO2:FIO2 ≤ 250 mmHg

FiO2-PEEP

475/508

54.5/56.9

15.6 ± 3.9/10.1 ± 3.0

282/193 vs. 307/201

144.8/144.6

Mercat/2008 [15]

4

PaO2:FIO2 ≤ 300 mmHg

HPa:Pplat

LPb: FiO2-PEEP

385/382

60/60

14.6 ± 3.2/7.1 ± 1.8

260/125 vs. 256/126

144/143

Talmor/2008 [16]

3

PaO2:FIO2 ≤ 200 mmHg

HPa:Transpulmonary pressure

LPb:FiO2-PEEP

30/31

54.5/51.2

17 ± 6.0/10 ± 4.0

19/11 vs. 17/14

91/107

Huh/2009 [17]

3

PaO2:FIO2 ≤ 200 mmHg

HPa:saturation decrease more than 2% and drop of static compliance

LPb:FiO2-PEEP

30/27

55/62

 

18/12 vs. 17/10

115/110

ART/2017 [8]

3

PaO2:FIO2 ≤ 200 mmHg

HPa: Maximum alveolar recruitment by compliance + 2 cmH2O

LPb: FiO2-PEEP

501/509

51.3/56

16.8 ± 3.8/13.0 ± 0.3

313/188 vs. 318/191

119.5/117.2

  1. aHP High PEEP group, bLP Low PEEP group, cLIP lower inflection point