Increased circulating microRNA-122 is associated with mortality and acute liver injury in the acute respiratory distress syndrome

Table 5 Cox regression analysis in patients with ARDS referring relative expression of miR-122

(Co) variable	Multivariate
	Initial			Restricted
	p-value	HR	95%- CI	p-value	HR	95%- CI
miR-122 ≤ 0.01 [2^-∆CT]	–	1		–	1
miR-122 > 0.01 [2^-∆CT]	0.021	5.392	1.285–22.619	0.016	4.441	1.197–16.110
Age [yrs]	0.033	1.048	1.004–1.095	0.013	1.047	1.010–1.087
SOFA score [per unit]	0.354	1.029	0.969–1.092
Platelet count [10⁹/l]	0.065	0.992	0.984–1.000	0.002	0.991	0.985–0.997
Bilirubin concentration [mg/dl]	0.074	1.299	0.975–1.730	0.103	1.239	0.957–1.603
AST activity [U/l]	0.121	1.002	0.999–1.004
GLDH activity [U/l]	0.646	1.001	0.998–1.003
INR	0.404	1.012	0.991–1.034
PTT [s]	0.574	1.004	0.989–1.020
Procalcitonin concentration [ng/ml]	0.737	1.000	0.998–1.003

HR Hazard ratio point estimates, 95% CI, and p-values (two-sided) from Wald tests are reported, 2^-∆CT: relative expression level of miRNA 122, SOFA Sepsis-related Organ Failure Assessment score, AST Aspartate aminotransferase, GLDH Glutamate dehydrogenase, PTT Partial thromboplastin time

ISSN: 1471-2253