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Table 4 Cox regression analysis in patients with ARDS referring ALI-definition of the Acute Liver Failure Study Group of the UTSWMC

From: Increased circulating microRNA-122 is associated with mortality and acute liver injury in the acute respiratory distress syndrome

(Co) variable

Multivariate

 

Initial

Restricted

 

p-value

HR

95%- CI

p-value

HR

95%- CI

Patients without ALI

1

 

1

 

Patients with ALI

< 0.001

8.377

2.994–23.436

< 0.001

7.645

2.959–19.756

Age [yrs.]

0.073

1.039

0.996–1.084

0.015

1.048

1.009–1.089

SOFA score [per unit]

0.457

1.023

0.964–1.085

   

Platelet count [109/l]

0.094

0.995

0.989–1.001

0.045

0.995

0.990–1.000

GLDH activity [U/l]

0.898

1.000

0.998–1.001

   

AST activity [U/l]

0.312

1.000

1.000–1.001

   

PTT activity [s]

0.534

1.004

0.992–1.015

   

Procalcitonin concentration [ng/ml]

0.350

0.999

0.998–1.001

   
  1. HR Hazard ratio point estimates, 95% CI, and p-values (two-sided) from Wald tests are reported, ALI Acute Liver Injury according the study inclusion criteria of the Acute Liver Failure Study Group of the UTSWMC, SOFA Sepsis-related Organ Failure Assessment score, GLDH Glutamate dehydrogenase, AST Aspartate aminotransferase, PTT Partial thromboplastin time