Increased circulating microRNA-122 is associated with mortality and acute liver injury in the acute respiratory distress syndrome

Table 2 Correlation between relative miRNA-122 expression (ΔCT) with other laboratory markers and haemodynamic variables

		p value	Spearman’s correlation coefficient (r)
Liver damage
- AST activity		< 0.001	0.537
- ALT activity	Day 1	< 0.001	0.495
	Day 5	< 0.001	0.523
	Day 10	0.004	0.288
	Day 15	0.003	0.329
	Peak_30day	< 0.001	0.490
- GLDH activity		< 0.001	0.489
- LDH activity		< 0.001	0.494
Cholestasis
- GGT activity		0.659
- AP activity		0.610
Liver function
- Bilirubin concentration	Day 1	0.025	0.206
	Day 5	0.032	0.204
	Day 10	0.496
	Day 15	0.641
	Peak_30day	0.070
- Direct bilirubin concentration		0.003	0.278
- INR	Day 1	0.001	0.308
	Day 5	0.017	0.227
	Day 10	0.155
	Day 15	0.337
	Peak_30day	0.002	0.284
Inflammation
- C-reactive protein concentration		0.872
- Procalcitonin concentration		0.274
- Interleukin-6 concentration		0.132
- TNF-Alpha concentration		0.425
- White blood cell count		0.720
Cardiovascular function
- Cardiac Index		0.386
- Stroke Volume Index		0.369
- Systemic Vascular Resistance Index		0.271
- Mid arterial pressure		0.001	−0.320
Right heart burden
- Mid pulmonary artery pressure		0.886
- Central venous pressure		0.533

ALT Alanine aminotransferase, AST Aspartate aminotransferase, GLDH Glutamate dehydrogenase, LDH Lactate dehydrogenase, GGT Gamma-glutamyl transferase, AP alkaline phosphatase, TNF Tumour necrosis factor; Peak_30day: Peak value of 30 day oberservation period; not labelled measurements were taken on day 1

ISSN: 1471-2253