Table 1 Baseline characteristic of survivors and non-survivors (30 days)
Variable | Survivors n = 82 (69%) | Non-survivors n = 37 (31%) | P-value |
|---|---|---|---|
Age yrs. (range/± SD) | 42.1 (18–70/±14.5) | 47.2 (22–64/±10.8) | 0.055 |
Male gender (%) | 50 (61) | 21 (57) | 0.664 |
Aetiology of ARDS | 0.663 | ||
- Pneumonia (other than H1N1) | 51 (62%) | 25 (68%) | 0.572 |
- H1N1-Infection | 19 (23%) | 8 (21%) | 0.852 |
- Extrapulmonary Sepsis | 7 (9%) | 1 (3%) | 0.239 |
- Other | 5 (6%) | 3 (8%) | 0.925 |
Body mass index (kg/m2) | 27.7 (±6.3) | 26.8 (± 5.6) | 0.440 |
Mean pulmonary artery pressure (mmHg) | 35.0 [30–39] | 36 [28–39] | 0.961 |
Pulmonary vascular resistance index (dyn*s/cm5*m2) | 333 [206–472] | 318 [205–453] | 0.942 |
C-reactive protein concentration (mg/dl) | 26.3 [14.8–34.7] | 20.3 [13,6–28.2] | 0.510 |
Procalcitonin concentration (ng/ml) | 1.8 [0.6–11.4] | 8.3 [1.1–48.3] | 0.012 |
Leukocyte concentration (*109/l) | 14.7 [8.6–21.6] | 12.1 [8.8–20.6] | 0.416 |
AST activity (U/l) | 68.5 [37.0–134,3] | 85.5 [66.5–293.0] | 0.001 |
ALT activity (U/l) | 39.0 [23.8–63.3] | 54.0 [25.5–106.5] | 0.006 |
Total bilirubin concentration (mg/dl) | 0.6 [0.4–1.3] | 1.5 [0.7–3.4] | < 0.001 |
GLDH activity (U/l) | 6.6 [3.3–11.7] | 20.7 [6.5–111.7] | 0.003 |
INR | 1.2 [1.0–1.5] | 1.4 [1.0–1.7] | 0.071 |
Platelet Count (/nl) | 171 [115–249] | 70.5 [42.5–159] | 0.002 |
PTT (s) | 38 [33–63] | 66 [45–100] | 0.033 |
ECMO therapy (%) | 21 (28) | 11 (33) | 0.548 |
Dialysis (%) | 39 (58) | 21 (68) | 0.172 |
Cardiovascular disease (%) | 11 (13) | 7 (19) | 0.428 |
Prior lung disease (%) | 11 (13) | 6 (16) | 0.686 |
SAPS II | 47.7 (±20.8) | 53.8 (±16.9) | 0.158 |
Lung injury score | 3.2 (±0.56) | 3.2 (±0.52) | 0.507 |
SOFA | 12.5 (±6.2) | 15.3 (±6.0) | 0.025 |
Mean Airway Pressure (mmHg) | 26.5 [23.5–29.6] | 27.3 [24.2–30.4] | 0.285 |
Horowitz-index upon ICU admission | 112.5 [73–191.5] | 90.5 [65.5–204.3] | 0.295 |