From: Effects of acute ethanol intoxication in an ovine peritonitis model
Groups | -2 h | 0 h (baseline = sepsis induction) | 4 h | 8 h | 12 h | 16 h | Mean diff. (p)b | ||
---|---|---|---|---|---|---|---|---|---|
Group | Group time interaction | ||||||||
Hemodynamics | |||||||||
Heart rate (/min) | Ethanol Control | 91 ± 16 88 ± 8 | 101 ± 21 100 ± 7 | 138 ± 28 130 ± 25 | 138 ± 19 122 ± 13 | 148 ± 23 122 ± 17 | 147 ± 28 149 ± 41 | 0.90 | 0.96 |
Mean arterial pressure (mmHg) | Ethanol Control | 90 ± 7 93 ± 19 | 92 ± 12 96 ± 7 | 87 ± 11 100 ± 16 | 63 ± 16 92 ± 18 | 52 ± 12 69 ± 17 | 47 ± 11 52 ± 15 | 0.60 | 0.11 |
Pulmonary artery occlusion pressure (mmHg) | Ethanol Control | 5 ± 4 6 ± 2 | 4 ± 2 4 ± 2 | 2 ± 1 4 ± 2 | 3 ± 2 5 ± 3 | 3 ± 2 5 ± 3 | 5 ± 5 7 ± 2 | 0.33 | 0.34 |
Cardiac index (L/min/m2) | Ethanol Control | 4.5 ± 1.0 4.4 ± 0.7 | 5.8 ± 1.6 4.9 ± 1.2 | 5.7 ± 1.2 5.6 ± 1.0 | 6.2 ± 1.6 6.3 ± 1.0 | 5.6 ± 1.9 5.6 ± 1.7 | 6.3 ± 3.1 4.5 ± 2.0 | 0.82 | 0.90 |
Systemic vascular resistance index (dyn·s/cm5·m2) | Ethanol Control | 2414 ± 737 2665 ± 382 | 2929 ± 738 2948 ± 632 | 1845 ± 292 2096 ± 757 | 1530 ± 355 1790 ± 655 | 1280 ± 336 1369 ± 316 | 991 ± 249 1567 ± 631 | 0.33 | 0.92 |
Other parameters | |||||||||
Blood temperature (°C) | Ethanol Control | 39.0 ± 0.7 38.4 ± 0.7 | 39.3 ± 1.0 38.9 ± 1.1 | 39.9 ± 1.1 39.5 ± 1.1 | 40.5 ± 1.2 40.0 ± 1.2 | 41.0 ± 1.0 40.6 ± 1.1 | 41.0 ± 1.3 40.9 ± 1.1 | 0.31 | 0.02 |
Mixed venous oxygen saturation (%) | Ethanol Control | 69.2 ± 9.7 66.4 ± 9.2 | 70.7 ± 8.6 69.5 ± 8.9 | 74.3 ± 7.6 74.8 ± 4.8 | 71.0 ± 15.6 76.5 ± 6.4 | 62.0 ± 20.2 72.7 ± 8.6 | 63.9 ± 13.6 60.5 ± 16.8 | 0.63 | 0.45 |
Cumulative fluid administration (mL/kg) | Ethanol Control | – – | 0 0 | 41 ± 7 38 ± 6 | 96 ± 8 90 ± 13 | 144 ± 20 144 ± 22 | 207 ± 32 176 ± 27 | 1.00 | 0.01 |
Urine output (mL/kg/h) | Ethanol Control | – – | 1.9 ± 1.5 2.0 ± 1.3 | 1.7 ± 1.0 1.6 ± 0.8 | 1.1 ± 1.0 1.6 ± 1.2 | 0.1 ± 0.2 0.7 ± 0.4 | 0.1 ± 0.1 0.3 ± 0.5 | 0.90 | 0.73 |
PaO2/FIO2 ratio | Ethanol Control | 447 ± 54 453 ± 80 | 433 ± 71 441 ± 67 | 393 ± 81 409 ± 43 | 305 ± 115 389 ± 62 | 235 ± 121 344 ± 76 | 216 ± 118 261 ± 126 | 0.66 | 0.12 |
Arterial pH | Ethanol Control | 7.42 ± 0.07 7.44 ± 0.05 | 7.40 ± 0.08 7.43 ± 0.07 | 7.33 ± 0.09 7.43 ± 0.07 | 7.29 ± 0.09 7.40 ± 0.07 | 7.17 ± 0.13 7.33 ± 0.09 | 7.09 ± 0.15 7.17 ± 0.20 | 0.93 | 0.08 |
Arterial lactate (mmol/L) | Ethanol Control | 0.6 ± 0.4 0.6 ± 0.3 | 1.5 ± 0.9 0.8 ± 0.6 | 3.5 ± 1.7 1.0 ± 0.8 | 4.0 ± 2.6 1.0 ± 0.7 | 6.1 ± 5.0 2.2 ± 1.7 | 5.6 ± 4.0 5.6 ± 3.5 | 0.93 | 0.09 |
Organ/tissue flow | |||||||||
Renal artery flow a | Ethanol Control | 0.90 ± 0.17 0.94 ± 0.16 | 1 1 | 1.04 ± 0.27 1.14 ± 0.29 | 0.83 ± 0.60 1.24 ± 0.42 | 0.46 ± 0.32 0.83 ± 0.33 | 0.36 ± 0.09 0.43 ± 0.34 | 0.96 | 0.19 |
Brain laser-Doppler flowmetry a | Ethanol Control | 1.02 ± 0.17 1.08 ± 0.20 | 1 1 | 1.17 ± 0.11 1.14 ± 0.14 | 1.10 ± 0.32 1.08 ± 0.19 | 1.09 ± 0.34 0.93 ± 0.28 | 0.71 ± 0.10 0.77 ± 0.55 | 0.46 | 1.00 |
Cerebral microdialysis analysis | |||||||||
Glucose (mg/dL) | Ethanol Control | – – | 30.7 ± 13.2 19.8 ± 11.6 | 34.6 ± 11.2 23.8 ± 12.5 | 26.6 ± 9.0 19.9 ± 11.3 | 19.6 ± 7.7 19.6 ± 16.5 | 16.6 ± 4.5 17.4 ± 23.5 | 0.17 | 0.12 |
Lactate (mmol/L) | Ethanol Control | – – | 2.1 ± 0.9 1.4 ± 0.8 | 3.8 ± 1.3 3.4 ± 0.9 | 4.5 ± 1.6 4.3 ± 1.3 | 5.2 ± 2.2 4.6 ± 1.5 | 4.2 ± 2.1 6.1 ± 2.5 | 0.41 | 0.92 |
Pyruvate (μmol/L) | Ethanol Control | – – | 136 ± 68 93 ± 39 | 234 ± 97 199 ± 107 | 287 ± 139 201 ± 119 | 259 ± 122 185 ± 83 | 136 ± 72 125 ± 83 | 0.36 | 0.88 |
Lactate/pyruvate ratio | Ethanol Control | – – | 16 ± 5 19 ± 10 | 17 ± 5 21 ± 9 | 17 ± 6 29 ± 18 | 21 ± 7 31 ± 17 | 32 ± 10 55 ± 35 | 0.51 | 0.79 |