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Table 1 Evolution of measured variables in the two groups (ethanol, n = 7 vs. control, n = 7)

From: Effects of acute ethanol intoxication in an ovine peritonitis model

 

Groups

-2 h

0 h

(baseline = sepsis induction)

4 h

8 h

12 h

16 h

Mean diff. (p)b

Group

Group time interaction

Hemodynamics

 Heart rate (/min)

Ethanol

Control

91 ± 16

88 ± 8

101 ± 21

100 ± 7

138 ± 28

130 ± 25

138 ± 19

122 ± 13

148 ± 23

122 ± 17

147 ± 28

149 ± 41

0.90

0.96

 Mean arterial pressure (mmHg)

Ethanol

Control

90 ± 7

93 ± 19

92 ± 12

96 ± 7

87 ± 11

100 ± 16

63 ± 16

92 ± 18

52 ± 12

69 ± 17

47 ± 11

52 ± 15

0.60

0.11

 Pulmonary artery occlusion pressure (mmHg)

Ethanol

Control

5 ± 4

6 ± 2

4 ± 2

4 ± 2

2 ± 1

4 ± 2

3 ± 2

5 ± 3

3 ± 2

5 ± 3

5 ± 5

7 ± 2

0.33

0.34

 Cardiac index (L/min/m2)

Ethanol

Control

4.5 ± 1.0

4.4 ± 0.7

5.8 ± 1.6

4.9 ± 1.2

5.7 ± 1.2

5.6 ± 1.0

6.2 ± 1.6

6.3 ± 1.0

5.6 ± 1.9

5.6 ± 1.7

6.3 ± 3.1

4.5 ± 2.0

0.82

0.90

 Systemic vascular resistance index (dyn·s/cm5·m2)

Ethanol

Control

2414 ± 737

2665 ± 382

2929 ± 738

2948 ± 632

1845 ± 292

2096 ± 757

1530 ± 355

1790 ± 655

1280 ± 336

1369 ± 316

991 ± 249

1567 ± 631

0.33

0.92

Other parameters

 Blood temperature (°C)

Ethanol

Control

39.0 ± 0.7

38.4 ± 0.7

39.3 ± 1.0

38.9 ± 1.1

39.9 ± 1.1

39.5 ± 1.1

40.5 ± 1.2

40.0 ± 1.2

41.0 ± 1.0

40.6 ± 1.1

41.0 ± 1.3

40.9 ± 1.1

0.31

0.02

 Mixed venous oxygen saturation (%)

Ethanol

Control

69.2 ± 9.7

66.4 ± 9.2

70.7 ± 8.6

69.5 ± 8.9

74.3 ± 7.6

74.8 ± 4.8

71.0 ± 15.6

76.5 ± 6.4

62.0 ± 20.2

72.7 ± 8.6

63.9 ± 13.6

60.5 ± 16.8

0.63

0.45

 Cumulative fluid administration (mL/kg)

Ethanol

Control

0

0

41 ± 7

38 ± 6

96 ± 8

90 ± 13

144 ± 20

144 ± 22

207 ± 32

176 ± 27

1.00

0.01

 Urine output (mL/kg/h)

Ethanol

Control

1.9 ± 1.5

2.0 ± 1.3

1.7 ± 1.0

1.6 ± 0.8

1.1 ± 1.0

1.6 ± 1.2

0.1 ± 0.2

0.7 ± 0.4

0.1 ± 0.1

0.3 ± 0.5

0.90

0.73

 PaO2/FIO2 ratio

Ethanol

Control

447 ± 54

453 ± 80

433 ± 71

441 ± 67

393 ± 81

409 ± 43

305 ± 115

389 ± 62

235 ± 121

344 ± 76

216 ± 118

261 ± 126

0.66

0.12

 Arterial pH

Ethanol

Control

7.42 ± 0.07

7.44 ± 0.05

7.40 ± 0.08

7.43 ± 0.07

7.33 ± 0.09

7.43 ± 0.07

7.29 ± 0.09

7.40 ± 0.07

7.17 ± 0.13

7.33 ± 0.09

7.09 ± 0.15

7.17 ± 0.20

0.93

0.08

 Arterial lactate (mmol/L)

Ethanol

Control

0.6 ± 0.4

0.6 ± 0.3

1.5 ± 0.9

0.8 ± 0.6

3.5 ± 1.7

1.0 ± 0.8

4.0 ± 2.6

1.0 ± 0.7

6.1 ± 5.0

2.2 ± 1.7

5.6 ± 4.0

5.6 ± 3.5

0.93

0.09

Organ/tissue flow

 Renal artery flow a

Ethanol

Control

0.90 ± 0.17

0.94 ± 0.16

1

1

1.04 ± 0.27

1.14 ± 0.29

0.83 ± 0.60

1.24 ± 0.42

0.46 ± 0.32

0.83 ± 0.33

0.36 ± 0.09

0.43 ± 0.34

0.96

0.19

 Brain laser-Doppler flowmetry a

Ethanol

Control

1.02 ± 0.17

1.08 ± 0.20

1

1

1.17 ± 0.11

1.14 ± 0.14

1.10 ± 0.32

1.08 ± 0.19

1.09 ± 0.34

0.93 ± 0.28

0.71 ± 0.10

0.77 ± 0.55

0.46

1.00

Cerebral microdialysis analysis

         

 Glucose (mg/dL)

Ethanol

Control

30.7 ± 13.2

19.8 ± 11.6

34.6 ± 11.2

23.8 ± 12.5

26.6 ± 9.0

19.9 ± 11.3

19.6 ± 7.7

19.6 ± 16.5

16.6 ± 4.5

17.4 ± 23.5

0.17

0.12

 Lactate (mmol/L)

Ethanol

Control

2.1 ± 0.9

1.4 ± 0.8

3.8 ± 1.3

3.4 ± 0.9

4.5 ± 1.6

4.3 ± 1.3

5.2 ± 2.2

4.6 ± 1.5

4.2 ± 2.1

6.1 ± 2.5

0.41

0.92

 Pyruvate (μmol/L)

Ethanol

Control

136 ± 68

93 ± 39

234 ± 97

199 ± 107

287 ± 139

201 ± 119

259 ± 122

185 ± 83

136 ± 72

125 ± 83

0.36

0.88

 Lactate/pyruvate ratio

Ethanol

Control

16 ± 5

19 ± 10

17 ± 5

21 ± 9

17 ± 6

29 ± 18

21 ± 7

31 ± 17

32 ± 10

55 ± 35

0.51

0.79

  1. Values are presented as mean ± SD. a, relative flow with baseline flow defined as 1. b, mixed model