Time after reperfusion | Group S (n = 10) | Group A (n = 10) | Group B (n = 10) | Group C (n = 10) | Group D (n = 10) | P value |
|---|
8 h | 0 (0) ¶ | 3.5 (1.0) | 3.0 (1.0) | 3.0 (1.0) | 3.0 (1.0) | <  0.001 |
1 day | 0 (0) ¶ | 3.0 (1.0) | 3.5 (1.0) | 4.0 (1.0) | 3.0 (0)* | <  0.001 |
3 day | 0 (0) ¶ | 4.0 (1.0) | 4.0 (1.0) | 4.0 (1.0) | 2.5 (1.0)* †‡ | <  0.001 |
5 day | 0 (0) ¶ | 4.0 (1.0) | 4.0 (1.0) | 4.0 (1.0) | 2.5 (1.0)* †‡ | <  0.001 |
7 day | 0 (0) ¶ | 3.5 (1.0) | 4.0 (1.0) | 4.0 (1.0) | 2.0 (1.0)* †‡ | <  0.001 |
- 0 = normal; 1 = the animal walks normally, but legs are weak, and the animal cannot pull the legs if they are held by the examiner; 2 = the animal assumes normal body posture on a flat surface and is able to walk, but there is ataxia or spasticity; 3 = the animal is able to walk on its knuckles, or able to walk on the feet without proper stepping; 4 = the animal drags its legs, but there is movement at the knees; and 5 = the animal drags legs without significant movements in the lower limbs and either spasticity or flaccidity is present. Data are presented as median (IQR). Group S: sham group; Group A: control group; Group B: 0.5 mg/kg simvastatin group; Group C: 1 mg/ kg simvastatin group; Group D: 10 mg/kg simvastatin group
- ¶: P < 0.001 compared with Group A,B, C and D; *: P < 0.0125 compared with Group C; †: P < 0.0125 compared with Group B; ‡: P < 0.0125 compared with Group A;
