Fig. 2

Representative microphotographs of the spinal cord from rats in each group. Group (a), group (b), and group (c) show similar features. Motor neurons suggest ischemic changes with shrunken nuclei and massive pericellular edema. Very few normal-looking motor neurons were observed. Grey matter shows spongy-like appearance due to marked vacuolization, and many infiltrating cells can be observed in remained gray matter. On the contrary, motor neurons of Group (d) show no massive vacuolization with minimal degree of pericellular edema. More intact motor neurons are observed. Group (s): sham group; Group (a): control group; Group (b): 0.5 mg/kg simvastatin group; Group (c): 1 mg/ kg simvastatin group; Group (d): 10 mg/kg simvastatin group