Skip to main content

Table 2 Summary of serum PEA, OEA, AEA, 2-AG, and cortisol levels at baseline and 4 h after TKA surgery. Group by time interactions for each metabolite are also shown

From: Intrathecal morphine administration reduces postoperative pain and peripheral endocannabinoid levels in total knee arthroplasty patients: a randomized clinical trial

 

Time

Placebo

Morphine

Estimated Mean Difference in Change Over Time (95% Confidence Interval)

P-value (ANOVA Interaction)

Mean

SD

N

Mean

SD

N

  

PEA

Baseline

1.561

0.481

17

1.452

0.497

15

−1.310 (−2.237, −0.382)

0.0048

4 h post-op

2.194

1.386

17

0.775

0.184

15

OEA

Baseline

2.101

1.009

18

1.201

0.484

15

−0.819 (−1.712, 0.073)

0.0706

4 h post-op

2.392

1.438

18

0.673

0.245

15

AEA

Baseline

0.260

0.139

18

0.089

0.055

15

−0.014 (−0.116, 0.089)

0.7856

4 h post-op

0.223

0.144

18

0.038

0.023

15

2-AG

Baseline

3.502

1.605

18

1.499

1.465

15

−2.286 (−6.617, 2.145)

0.3008

4 h post-op

8.568

6.932

18

4.279

5.282

15

Cortisol

Baseline

13.250

7.176

16

14.025

5.528

14

−13.730 (−23.602, −3.859)

0.0081

4 h post-op

22.937

13.712

16

9.981

6.650

14