Argatroban (n = 17) | Lepirudin (n = 18) | p | |
---|---|---|---|
Gender (male/female) | 12/5 | 10/8 | 0.463 |
Age (years) | 72 ± 10 | 59 ± 18 | 0.053 |
Height (cm) | 172 ± 10 | 171 ± 8 | 0.732 |
Weight (kg) | 89 ± 19 | 76 ± 19 | 0.067 |
Body mass index | 30 ± 9 | 26 ± 6 | 0.126 |
Systolic blood pressure (mmHg) | 123 ± 18 | 122 ± 21 | 0.684 |
Diastolic blood pressure (mmHg) | 57 ± 10 | 58 ± 11 | 0.757 |
Mean arterial blood pressure (mmHg) | 81 ± 14 | 76 ± 13 | 0.443 |
Heart beats per minute | 93 ± 19 | 93 ± 18 | 0.883 |
Glasgow coma scale | 8 ± 5 | 6 ± 4 | 0.232 |
Simplified Acute Physiology Score | 38 ± 16 | 35 ± 15 | 0.732 |
Sequential Organ Failure Assessment Score | 11 ± 7 | 10 ± 4 | 0.636 |
aPTT (seconds) | 47 ± 8 | 45 ± 9 | 0.732 |
Quick (%) | 79 ± 24 | 81 ± 16 | 0.832 |
INR | 1.2 ± 0.3 | 1.2 ± 0.3 | 0.807 |
TZ (seconds) | 30 ± 26 | 20 ± 7 | 0.568 |
Fibrinogen (mg/dl) | 705 ± 242 | 721 ± 159 | 0.851 |
Antithrombin (%) | 79 ± 22 | 83 ± 20 | 0.467 |
Leukocyts (/nl) | 11.9 ± 3.8 | 15.6 ± 11 | 0.684 |
Red blood cell count (/pl) | 3.4 ± 0.3 | 3.2 ± 0.3 | 0.184 |
Hemoglobin (g/dl) | 9.8 ± 0.9 | 9.4 ± 0.9 | 0.219 |
Hematocrit (%) | 31 ± 3 | 29 ± 3 | 0.077 |
Thrombocytes (/nl) | 130 ± 106 | 189 ± 198 | 0.386 |
Sodium (mmol/l) | 142 ± 5 | 141 ± 4. | 0.763 |
Potassium (mmol/l) | 4.4 ± 0.4 | 4.5 ± 0.4 | 0.363 |
Calcium (mmol/l) | 1.17 ± 0.05 | 1.27 ± 0.24 | 0.026* |
Creatinine (mg/dl) | 1.9 ± 1.2 | 1.8 ± 1.2 | 0.658 |
Urea (mg/dl) | 89 ± 46 | 93 ± 48 | 0.865 |
Total protein (g/dl) | 5.5 ± 0.3 | 5.7 ± 0.3 | 0.299 |
Albumin (g/dl) | 2.5 ± 0.4 | 2.4 ± 0.4 | 0.503 |
Bilirubin total(mg/dl) | 1.8 ± 2.7 | 5.8 ± 10.4 | 0.118 |
GOT (AST; U/l) | 307 ± 547 | 273 ± 642 | 0.606 |
GPT (ALT; U/l) | 189 ± 225 | 156 ± 303 | 0.145 |
γ-GT (U/l) | 196 ± 192 | 243 ± 241 | 0.497 |
LDH (U/l) | 430 ± 176 | 469 ± 167 | 0.401 |
CK total (U/l) | 341 ± 830 | 946 ± 2158 | 0.161 |
CK-MB (U/l) | 18.8 ± 19.1 | 38.6 ± 34.4 | 0.310 |
Troponin T (ng/ml) | 1.11 ± 1.81 | 0.51 ± 0.81 | 0.841 |
CRP (mg/dl) | 16 ± 8 | 18 ± 9 | 0.381 |
Glucose (mg/dl) | 124 ± 27 | 135 ± 22 | 0.259 |