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Table 1 Patient characteristics

From: Monitoring of argatroban and lepirudin anticoagulation in critically ill patients by conventional laboratory parameters and rotational thromboelastometry – a prospectively controlled randomized double-blind clinical trial

 

Argatroban (n = 17)

Lepirudin (n = 18)

p

Gender (male/female)

12/5

10/8

0.463

Age (years)

72 ± 10

59 ± 18

0.053

Height (cm)

172 ± 10

171 ± 8

0.732

Weight (kg)

89 ± 19

76 ± 19

0.067

Body mass index

30 ± 9

26 ± 6

0.126

Systolic blood pressure (mmHg)

123 ± 18

122 ± 21

0.684

Diastolic blood pressure (mmHg)

57 ± 10

58 ± 11

0.757

Mean arterial blood pressure (mmHg)

81 ± 14

76 ± 13

0.443

Heart beats per minute

93 ± 19

93 ± 18

0.883

Glasgow coma scale

8 ± 5

6 ± 4

0.232

Simplified Acute Physiology Score

38 ± 16

35 ± 15

0.732

Sequential Organ Failure Assessment Score

11 ± 7

10 ± 4

0.636

aPTT (seconds)

47 ± 8

45 ± 9

0.732

Quick (%)

79 ± 24

81 ± 16

0.832

INR

1.2 ± 0.3

1.2 ± 0.3

0.807

TZ (seconds)

30 ± 26

20 ± 7

0.568

Fibrinogen (mg/dl)

705 ± 242

721 ± 159

0.851

Antithrombin (%)

79 ± 22

83 ± 20

0.467

Leukocyts (/nl)

11.9 ± 3.8

15.6 ± 11

0.684

Red blood cell count (/pl)

3.4 ± 0.3

3.2 ± 0.3

0.184

Hemoglobin (g/dl)

9.8 ± 0.9

9.4 ± 0.9

0.219

Hematocrit (%)

31 ± 3

29 ± 3

0.077

Thrombocytes (/nl)

130 ± 106

189 ± 198

0.386

Sodium (mmol/l)

142 ± 5

141 ± 4.

0.763

Potassium (mmol/l)

4.4 ± 0.4

4.5 ± 0.4

0.363

Calcium (mmol/l)

1.17 ± 0.05

1.27 ± 0.24

0.026*

Creatinine (mg/dl)

1.9 ± 1.2

1.8 ± 1.2

0.658

Urea (mg/dl)

89 ± 46

93 ± 48

0.865

Total protein (g/dl)

5.5 ± 0.3

5.7 ± 0.3

0.299

Albumin (g/dl)

2.5 ± 0.4

2.4 ± 0.4

0.503

Bilirubin total(mg/dl)

1.8 ± 2.7

5.8 ± 10.4

0.118

GOT (AST; U/l)

307 ± 547

273 ± 642

0.606

GPT (ALT; U/l)

189 ± 225

156 ± 303

0.145

γ-GT (U/l)

196 ± 192

243 ± 241

0.497

LDH (U/l)

430 ± 176

469 ± 167

0.401

CK total (U/l)

341 ± 830

946 ± 2158

0.161

CK-MB (U/l)

18.8 ± 19.1

38.6 ± 34.4

0.310

Troponin T (ng/ml)

1.11 ± 1.81

0.51 ± 0.81

0.841

CRP (mg/dl)

16 ± 8

18 ± 9

0.381

Glucose (mg/dl)

124 ± 27

135 ± 22

0.259

  1. Data are median ± standard deviation.*p < 0.05