Table 1 Summarized Study Design of Included Randomized Trials
Study | Country | Surgery | Dexmedetomidine Dose | Control | Time and Duration of intervention or Control | No. of Patients | Clinical End Point | AKI Definition | Follow-Up |
|---|---|---|---|---|---|---|---|---|---|
Balkanay2015 I [17] | Turkey | On-PUMP CABG | 0.04μg/kg/h-0.05μg/kg/h | placebo | Start preCPB and last for 24 h | 31 vs 28 | AKI;MV duration; ICU stay; Hospital stay | RIFLE | In hospital |
Balkanay2015II [17] | Turkey | On-PUMP CABG | 0.04μg/kg/h-0.05μg/kg/h | placebo | Start preCPB and last for 24 h | 29 vs 28 | AKI;MV duration; ICU stay; Hospital stay | RIFLE | In hospital |
Cho 2015 [12] | Korea | Combined | 0.04μg/kg/h | placebo | Start immediately after anesthetic induction and last for 24 h | 100 vs100 | AKI; Mortality; ICU stay; | AKIN | In hospital |
DjaianiG 2016 [18] | Canada | Combined | 0.4μg/kg 0.2–0.7μg/kg/h | propofol | Start postsurgery and last for 24 h | 91 vs 92 | AKI; Mortality; MV duration; ICU stay; Hospital stay | NA | In hospital |
Leino 2011 [19] | Finland | On-PUMP CABG | 0.6 ng/ml | placebo | Start immediately after anesthetic induction and last for 4 h arrive ICU | 35 VS 31 | AKI; MV duration; | RIFLE | In hospital |
Li 2017 [14] | China | Combined | 0.1μg/kg/h-0.6μg/kg/h | placebo | Start preCPB and last until the end of MV | 142 vs143 | AKI;MV duration; ICU stay | KDIGO | 30 days after surgery |
Liu 2016 [20] | China | Combined | <1.5μg/kg/h | propofol | Start after surgery and last until the end of MV | 44 vs 44 | AKI; Mortality; MV duration; ICU stay; Hospital stay | AKIN | In hospital |
Park 2014 [13] | Korea | Combined | 0.5μg/kg 0.2–0.8μg/kg/h | remifentanil | Start after surgery and last until extubation | 67 vs 75 | AKI; MV duration; ICU stay; Hospital stay | Cr > 100%abovebaseline or new dialysis need | In hospital |
Shehabi2009 [21] | Australia | Combined | 0.1–0.7μg/kg/ml | morphine | Start within 1 h of adminssin to CICU until the removal of chest drains | 152 vs147 | AKI; Mortality; MV duration; ICU stay; Hospital stay | NA | 12 days after surgery |
Ammar 2016 [22] | Egypt | Combined | 1 μg/kg over 15 min, followed by 0.5 μg/kg/h | placebo | Start preCPB and last until 6 h after surgery | 25 vs 25 | AKI; Mortality; MV duration; ICU stay; Hospital stay | NA | 30 days after surgery |
Soliman 2016 [23] | Egypt | Aortic vascular surgery | 1 μg/kg 0.3 μg/kg/h | placebo | Start 15 min before induction maintained to the end of surgery | 75 vs 75 | AKI; Mortality; | Cr > 115 μmol/L | In hospital |