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Table 2 Hemodynamic values during intravenous infusion of study drug (DEX or NS)

From: Comparison of a loading dose of dexmedetomidine combined with propofol or sevoflurane for hemodynamic changes during anesthesia maintenance: a prospective, randomized, double-blind, controlled clinical trial

 

P + DEX group (n = 20)

S + DEX group (n = 20)

P + NS group (n = 20)

S + NS group (n = 20)

SBP (mmHg)

 T0

108(16)

119(13)

120(16)

125(11)

 T5

140(20)^^

122(13)

120(17)

124(12)

 T10

153(23)^^

126(17)

122(15)

124(10)

 ΔT5

32(17)**##

3(10)

0(4)

-1(5)

 ΔT10

45(20)**##

6(16)

2(6)

-1(5)

DBP (mmHg)

 T0

63(10)

70(10)

65(12)

70(7)

 T5

79(11)^^

71(7)

65(13)

70(8)

 T10

88(11)^^

71(11)

66(9)

70(7)

 ΔT5

17(10)**##

2(9)

0(2)

0(3)

 ΔT10

25(11)**##

2(14)

1(5)

0(4)

MAP (mmHg)

 T0

78(11)

86(9)

83(13)

88(7)

 T5

100(13)^^

88(7)

83(14)

88(9)

 T10

109(13)^^

90(11)

84(10)

88(7)

 ΔT5

22(11)**##

2(9)

0(2)

0(3)

 ΔT10

32(13)**##

4(14)

1(5)

0(4)

HR (bpm)

 T0

64(11)

72(9)

67(10)

64(7)

 T5

55(5)^^

59(8)^^

67(11)

64(6)

 T10

53(4)^^

58(9)^^

66(11)

63(7)

 ΔT5

−10(9)##

−13(10)&&

0(3)

−1(3)

 ΔT10

−11(11)##

−14(10)&&

0(4)

−1(3)

  1. Values are means (SDs). ^^P < 0.01, compared to T0; **P < 0.01, P + DEX group vs. S + DEX group; ##P < 0.01, P+ DEX group vs. P + NS group; &&P < 0.01, S+ DEX group vs. S + NS group
  2. SBP Systolic blood pressure, DBP Diastolic blood pressure, MAP Mean arterial pressure, HR Heart rate, T0 Just before continuous intravenous infusion of study drug, T5 5 min after continuous intravenous infusion of study drug, T10 The end of continuous intravenous infusion of study drug, ΔT5 = T5-T0, ΔT10 = T10-T0