Table 3 Evolution in ventilatory measurements
From: Low flow extracorporeal CO2 removal in ARDS patients: a prospective short-term crossover pilot study
| Â | Inclusion | Day 2 | Day 3 | Day4 | Day 5 | Difference | % change | p |
|---|---|---|---|---|---|---|---|---|
PPLAT (cmH2O) | 31.5 [28.8; 35.5] | 25.0 [22.5; 30.5] | 26.0 [22.0; 29.5] | 25.0 [22.0; 27.0] | 24.0 [21.0; 26.0] | 10.0 [4.5; 12.5] | −31.4 [−36.2; −15.4] | 0.008 |
VT (mL) | 334 [317; 469] | 300 [270; 353] | 318 [270; 390] | 300 [251; 344] | 308 [243; 347] | 69.0 [20.0; 90.0] | −20.9 [−26.3; −5.17] | 0.008 |
VT/PBW (mL/kg) | 6.85 [6.31; 7.48] | 5.60 [4.90; 6.05] | 5.80 [4.75; 6.45] | 5.30 [4.55; 6.20] | 5.00 [4.55; 5.95] | 1.6 [0.8; 2.15] | −23.7 [−31.3; −13.9] | 0.008 |
Driving Pressure: PPLAT –PEEP (cmH2O) | 19.0 [17.5; 24.0] | 14.0 [11.0; 18.5] | 15.0 [11.0; 19.0] | 15.0 [11.0; 17.0] | 14.0 [10.0; 16.5] | 9.0 [3.5; 12] | −39.1 [−52.2; −21.7] | 0.012 |
PEEP (cmH2O) | 12.0 [9.0; 12.75] | 11.0 [8.5; 14.5] | 11.0 [8.0; 13,5] | 10.0 [8.0; 11.50] | 10.0 [8.0; 10.0] | 2.0 [−1.0; 2.0] | 16.7 [−16.7; 16.7] | 0.305 |
Respiratory Rate | 32.0 [27.8; 33.0] | 30.0 [27.5; 31.5] | 30.0 [27.0; 31.5] | 30.0 [27.0; 33.5] | 30.0 [26.0; 33.5] | 3.0 [−1.0; 6.0] | 9.1 [−3.0; 20.0] | 0.235 |
pH | 7.21 [7.11; 7.23] | 7.33 [7.29; 7.38] | 7.38 [7.31; 7.42] | 7.39 [7.34; 7.44] | 7.43 [7.40; 7.44] | 0.23 [0.20; 0.26] | 3.19 [2.77; 3.63] | 0.008 |
PaO2/FiO2 (mmHg) | 83.0 [67.6; 105.4] | 131.4 [90.2; 212.7] | 137.2 [118.9; 223.8] | 142.0 [116.1; 245.5] | 233.6 [135.7; 320.1] | 91.9 [29.9; 213.8] | 144.0 [30.8; 232.2] | 0.011 |
PaCO2 (mmHg) | 68.3 [57.3; 86.2] | 50.3 [42.9; 63.9] | 51.5 [48.2; 62.2] | 56.8 [46.6; 63.1] | 59.3 [48.2; 60.9] | 14.6 [4.0; 35.8] | 22.2 [6.9; 38.0] | 0.021 |
HCO3− | 22.6 [22.1; 29.6] | 25.7 [20.3; 34.1] | 25.7 [25.3; 30.0] | 29.1 [27.9; 39.3] | 35.3 [29.4; 41.9] | −7.6 [−12.1; −3.2] | −34.2 [−51.2; −14.8] | 0.021 |
FiO2 | 0.83 [0.68; 1.00] | 0.55 [0.40; 0.75 | 0.55 [0.35; 0.73] | 0.60 [0.35; 0.73] | 0.50 [0.35; 0.73] | 0.25 [0.05; 0.5] | 45.5 [5.9; 50.0] | 0.017 |