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Fig. 4 | BMC Anesthesiology

Fig. 4

From: Membrane protein Nav1.7 contributes to the persistent post-surgical pain regulated by p-p65 in dorsal root ganglion (DRG) of SMIR rats model

Fig. 4

a-b Effects of pretreatment with i.t injection of PDTC (once daily from 1d before surgery until 10d after surgery) on the mechanical hyperalgesia induced by SMIR model (**P < 0.01,***P < 0.001,n = 6). c-d Western blotting result of nucleoprotein p-p65 from ipsilateral L4-L6 DRGs of SMIR surgery rats. Statistical summaries of western blot analysis: The expression of p-p65 protein was increased at 10d (n = 4) and 15d (n = 5) after SMIR surgery compared with incision groups, whereas pretreatment with PDTC (once daily from 1d before surgery until 7d after surgery) can prevent the activation of NF-κB at 10d (n = 4) and 15d (n = 5) compared with SMIR group (*P < 0.05 vs incision group; #P < 0.05 vs SMIR group)

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BMC Anesthesiology

ISSN: 1471-2253

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