Fig. 4
Propofol significantly inhibits CML growth in vivo and augments dasatinib’s inhibitor effect. Propofol dose-dependently decreases tumor size (a) and weight (b) in a CML xenograft mouse model. Combination of propofol and dasatinib is more effective in decreasing tumor size (c) and weight (d) than propofol or dasatinib alone. In combination studies, 20 mg/kg propofol and 5 mg/kg dasatinib was given to mice by intraperitoneal and oral administration, respectively. DMSO/Saline (20%/80%) was used as vehicle control. Tumour volume was calculated using the formula: length × width2/2. *p < 0.05, compared to control or single arm treatment