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Fig. 3 | BMC Anesthesiology

Fig. 3

From: Propofol enhances BCR-ABL TKIs’ inhibitory effects in chronic myeloid leukemia through Akt/mTOR suppression

Fig. 3

Propofol enhances imatinib’s effects in CML cells by suppressing Akt/mTOR signaling pathway. Representative western blot images showing the inhibitory effects of propofol alone (a) and combination of propofol and imatinib (b) on phosphorylation of Akt, mTOR and S6 in K562 cells. Propofol at 5 μM and imatinib at 1 μM were used for combination studies. Overexpression of constitutively active Akt (myr Akt) significantly reverses the effects of propofol in inhibiting proliferation (c) and inducing apoptosis (d) in K562 cells. DMSO (final concentration 0.5%) was used as control. *p < 0.05, compared to vector control

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BMC Anesthesiology

ISSN: 1471-2253

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