Fig. 2

Propofol is selectively active against CML CD34 progenitor cells and enhances dasatinib’s inhibitory effects. Propofol is more effective in inducing apoptosis (a) and inhibiting colony formation (b) in CML than NBM CD34 progenitor cells. Combination of propofol and dasatinib results in significant more apoptosis induction and colony formation inhibition than propofol or dasatinib alone in CML cells. Propofol at 5 μM and dasatinib at 200 nM were used for combination studies. DMSO (final concentration 0.5%) was used as control. *p < 0.05, compared to control or single drug alone