Table 1 Trial characteristics
Reference (Author and year) | Surgical procedure | N Gabapentin/Control | Intervention | Postoperative analgesia | Anesthetic technique | Bias assessment | |
|---|---|---|---|---|---|---|---|
Dose (mg) (mg/day a ) | Single/Continuous | ||||||
Cholecystectomy trials | |||||||
Bashir 2009 [24] | Laparoscopic cholecystectomy | 50/50 | 600 mg | Single | Not described | GA | Unclear |
Bekawi 2014 [26] | Laparoscopic cholecystectomy | 30/30 | 1200 mg (400 mg) | Continuous | NSAID Pethidine Tramadol | GA | Unclear |
Bhandari 2014 [27] | Laparoscopic cholecystectomy | 20/20 | 600 mg (600 mg) | Continuous | NSAID | GA | High |
Hosseini 2015 [48] | Laparoscopic cholecystectomy | 22/22 | 600 mg | Single | Morphine | GA | High |
Khademi 2009 [51] | Open cholecystectomy | 44/43 | 600 mg | Single | Pethidine | GA | High |
Mishra 2016 [63] | Laparoscopic cholecystectomy | 30/30 | 900 mg | Single | Tramadol | GA | High |
Neogi 2012 [64] | Laparoscopic cholecystectomy | 30/30 | 900 mg | Single | Tramadol | GA | High |
Panday 2004b [68] | Laparoscopic cholecystectomy | 153/153 | 300 mg | Single | Fentanyl | GA | Unclear |
Panday 2006 [70] | Laparoscopic cholecystectomy | 125/125 | 600 mg | Single | Fentanyl | GA | High |
Pathak 2013 [71] | Open cholecystectomy | 40/40 | 1200 mg | Single | Pethidine | GA | High |
Saeed 2013 [79] | Laparoscopic cholecystectomy | 50/50 | 600 mg | Single | Pethidine NSAID | GA | High |
Semira 2013 [81] | Laparoscopic cholecystectomy | 30/30 | 600 mg | Single | Not described | GA | High |
Sharma 2015 [83] | Laparoscopic cholecystectomy | 20/20 | 600 mg (600 mg) | Continuous | NSAID | GA | High |
Srivastava 2009 [85] | Open cholecystectomy | 60/60 | 600 mg | Single | Tramadol | GA | Low |
Syal 2010 [86] | Open cholecystectomy | 30/30 | 1200 mg | Single | Tramadol | GA | High |
Takmaz 2009 [87] | Open cholecystectomy | 30/15 | 900/1200 mg | Single | Tramadol Meripedine | GA | High |
Hysterectomy trials | |||||||
Ajori 2011 [20] | Abdominal hysterectomy | 69/69 | 600 mg | Single | Meripedine | GA | High |
Badawy 2014 [23] | Hysterectomy | 20/20 | 800 mg | Single | Meripedine Acetaminophen | GA | Unclear |
Behdad 2012 [25] | Hysterectomy | 30/31 | 100 mg (300 mg/d) | Continuous | An opioid | GA | High |
Dierking 2003 [33] | Abdominal hysterectomy (salphinooophrectomy) | 40/40 | 1200 mg (1800 mg/d) | Continuous | Morphine | GA | High |
Durmus 2006 [36] | Hysterectomy | 25/25 | 1200 mg | Single | Morphine | GA | Unclear |
Fassoulaki 2005 [39] | Abdominal hysterectomy | 29/30 | 400 mg (1600 mg/d) | Continuous | Morphine Paracetamol Codeine | GA | Low |
Fassoulaki 2006 [40] | Abdominal hysterectomy | 30/30 | 400 mg (1600 mg/d) | Continuous | Morphine Paracetamol Codeine Local anesthetic | GA | High |
Frouzanfard 2013 [41] | Abdominal hysterectomy | 25/25 | 1200 mg | Single | Morphine NSAID | GA | High |
Ghafari 2009 [42] | Abdominal hysterectomy and salphinooophrectomy | 33/33 | 300 mg (300 mg/d) | Continuous | Morphine | GA | Unclear |
Ghai 2011 [43] | Abdominal hysterectomy | 30/30 | 900 mg | Single | Morphine NSAID | GA | Low |
Gilron 2004 [44] | Abdominal hysterectomy | 23/24 | 1800 mg (1800 mg/d) | Continuous | Morphine | GA | High |
Joseph 2014 [50] | Abdominal hysterectomy | 25/25 | 600 mg | Single | Morphine | GA | High |
Khan 2013 [53] | Abdominal hysterectomy | 34/35 | 1200 mg | Single | Nalbuphine | GA | High |
Ram 2015 [75] | Abdominal hysterectomy | 30/30 | 900 mg | Single | NSAID | Spinal anesthesia | High |
Ray 2015 [77] | Abdominal hysterectomy | 30/30 | 300 mg | Single | NSAID | Spinal anesthesia | High |
Rorarius 2004 [78] | Vaginal hysterectomy | 45/45 | 600 mg | Single | Fentanyl | GA | High |
Sekhavet 2009 [80] | Abdominal hysterectomy | 49/49 | 600 mg (300 mg/d) | Continuous | Morphine NSAID | GA | Unclear |
Sen 2009a [82] | Abdominal hysterectomy and salphinooophrectomy | 20/20 | 1200 mg | Single | Morphine Acetaminophen Codeine | GA | High |
Turan 2003a [88] | Abdominal hysterectomy and salphinooophrectomy | 25/25 | 1200 mg | Single | Tramadol | GA | High |
Turan 2006 [90] | Abdominal hysterectomy and salphinooophrectomy | 25/25 | 1200 mg (1200 mg/d) | Continuous | Acetaminophen Codeine | GA | High |
Verma 2008 [94] | Abdominal hysterectomy | 25/25 | 300 mg | Single | Epidural analgesia | Spinal-epidural anesthesia | High |
Mastectomy trials | |||||||
Amr 2009 [21] | Radical or partial mastectomy | 50/50 | 300 mg (300 mg/d) | Continuous | Morphine Acetaminophen Codeine | GA | Unclear |
Azemati 2013 [22] | Radical mastectomy or quandrandectomy and axillary node dissection | 50/50 | 600 mg | Single | Pethidine Acetaminophen | GA | High |
Bharti 2012 [28] | Total mastectomy with axillary node dissection | 20/20 | 600 mg | Single | Morphine NSAID | GA | Unclear |
Butt 2010 [29] | Mastectomy | 50/50 | 1200 mg | Single | Morphine | GA | Unclear |
Dirks 2002 [34] | Unilateral radical mastectomy with axillary dissection | 31/34 | 1200 mg | Single | Morphine | GA | High |
Doha 2010 [35] | Radical mastectomy | 30/30 | 1200 mg | Single | Tramadol NSAID | GA | High |
Fassoulaki 2002 [38] | Radical mastectomy or lobectomy with axillary lymph node dissection | 25/25 | 400 mg (1200 mg/d) | Continuous | Propoxyphene Acetaminophen Codeine | GA | High |
Gosai 2015 [45] | Radical mastectomy | 30/30 | 600 mg | Single | NSAID | GA | High |
Grover 2009 [47] | Total mastectomy with axillary node dissection | 27/23 | 600 mg | Single | Morphine | GA | High |
Kim 2004 [55] | Mastectomy | 21/20 | 900 mg | Single | Fentanyl | GA | Unclear |
Metry 2008 [62] | Unilateral radical mastectomy and axillary dissection | 67/34 | 1200 mg | Single | Morphine | GA | High |
Orthopedic arthroplasty surgery trials | |||||||
Clarke 2009a [30] | Total knee arthroplasty | 29/7 | 600 mg (300/600/900 mg/d) | Single/continuous | Morphine NSAID Regional anesthesia | Spinal anesthesia and sedation | High |
Clarke 2009b [31] | Total hip arthroplasty | 76/39 | 600 mg | Single (pre/post-operative administration) | Morphine NSAID Acetaminophen Dexamethasone | Spinal anesthesia | Unclear |
Clarke 2014 [32] | Total knee arthroplasty | 95/84 | 600 mg | Single | Morphine NSAID Regional anesthesia | Spinal anesthesia and sedation | High |
Lunn 2015 [59] | Total knee arthroplasty | 186/99 | 900/600 mg (1300/900 mg/d) | Continuous | Sufentanil Oxycodone NSAID Acetaminophen Local infiltration analgesia | Spinal anesthesia and sedation | Low |
Paul 2013 [73] | Total knee arthroplasty | 52/49 | 600 mg (600 mg) | Continuous | Morphine NSAID Acetaminophen | Spinal anesthesia and sedation | Low |
Paul 2015 [72] | Total hip arthroplasty | 48/54 | 600 mg (600 mg) | Continuous | Morphine NSAID Acetaminophen | Spinal anesthesia and sedation | Low |
Spinal surgery trials | |||||||
Erten 2010 [37] | Laminectomy | 39/20 | 900/1200 mg | Single | Tramadol Pethidine NSAID | GA | High |
Khan 2010 [52] | Laminectomy | 150/25 | 600/900/1200 mg (600/900/1200 mg) | Continuous | Morphine | GA | Unclear |
Khurana 2013 [54] | Discoidectomy | 30/30 | 300 mg (900 mg/d) | Continuous | Tramadol NSAID | GA | Unclear |
Leung 2006 [58] | Spine surgery | 9/12 | 900 mg (900 mg/d) | Continuous | Hydromorphine | GA | Unclear |
Özgencil 2011 [66] | Laminectomy or discoidectomy | 30/30 | 1800 mg (1200 mg/d) | Continuous | Morphine | GA | Unclear |
Panday 2004a [67] | Discoidectomy | 80/20 | 300/600/900/1200 mg | Single | Fentanyl | GA | High |
Panday 2004c [69] | Discoidectomy | 28/28 | 300 mg | Single | Fentanyl | GA | Unclear |
Radhakrishnan 2005 [74] | Laminectomy or Discoidectomy | 30/30 | 800 mg (800 mg/d) | Continuous | Morphine | GA | High |
Turan 2003b [89] | Discoidectomy or spinal fusion | 25/25 | 1200 mg | Single | Morphine | GA | High |
Vahedi 2011 [92] | Laminectomy or Discoidectomy | 36/40 | 300 mg | Single | Morphine | GA | High |
Vasigh 2015 [93] | Laminectomy | 38/38 | 600 mg (900 mg/d) | Continuous | Morphine | GA | High |
Thoracic surgery trials | |||||||
Grosen 2014 [46] | Thoracotomy for malignancies | 52/52 | 1200 mg (increasing dose to 1200 mg/d) | Continuous | Morphine NSAID Acetaminophen Epidural analgesia | GA | Low |
Hout 2007 [49] | Exploratory thoracotomy, pneumonectomy, lobectomy, segmentectomy, biopsy | 23/28 | 1200 mg | Single | Hydromorphine Epidural analgesia | GA | High |
Kinney 2011 [56] | Thoratectomy; Lobectomy; Wedge resection; Segmentectomy; Pneumonectomy; Chest wall resection | 57/68 | 600 mg | Single | Fentanyl NSAID Acetaminophen Epidural analgesia | GA | Low |
Kosucu 2013 [57] | Posterolateral or lateral thoracotomy | 29/31 | 1200 mg | Single | Morphine Meriphidine NSAID | GA | High |
Menda 2010 [61] | Coronary artery bypass graft | 30/30 | 600 mg | Single | Morphine Acetaminophen | GA | Unclear |
Omran 2005 [65] | Posterolateral thoracotomy for lobectomy | 25/25 | 1200 mg (1200 mg/d) | Continuous | Morphine | GA | Unclear |
Rapchuk 2009 [76] | Cardiac surgery via Sternum | 27/27 | 1200 mg (600 mg/d) | Continuous | Fentanyl Acetaminophen | GA | High |
Soltanzadeh 2011 [84] | Coronary artery bypass graft | 30/30 | 800 mg (400 mg/d) | Continuous | Morphine | GA | High |
Ucak 2011 [91] | Coronary artery bypass graft | 20/20 | 1200 mg (1200 mg/d) | Continuous | Tramadol Acetaminophen | GA | High |