Fig. 5
Sevoflurane increases brain cGMP levels in WT mice but not in GC-1−/− mice. Brain cGMP levels in wild-type mice (WT) and GC-1−/− mice inhaling 1.2% sevoflurane for 20 min. The control group (O2) breathed O2. Sevoflurane (Sevo) increased whole brain cGMP levels in WT mice, but not in GC-1−/− mice. Data presented as mean ± standard deviation. Adjusted P values: * P = 0.0355 vs. WT O2 and P = 0.0062 vs. GC-1−/− O2, # P = 0.0275 vs. WT Sevo, by one-way ANOVA. N = 13, 10, 8, 7 in WT O2, WT Sevo, GC-1−/− O2, GC-1−/− Sevo, respectively