Combination of gabapentin and ramosetron for the prevention of postoperative nausea and vomiting after gynecologic laparoscopic surgery: a prospective randomized comparative study

Table 3 Incidence of adverse effects, VNRS for pain and patients received rescue drug up to 48 h after anesthesia

Parameters	Group G (n = 40)	Group R (n = 44)	Group GR (n = 40)	P value (overall)
Adverse effects
Dizziness	5	3	4	0.677
Headache	2	1	2	0.761
Drowsiness	1	0	1	0.572
VNRS for postoperative pain
postoperative 0–2 h	6.4 ± 2.0	7.0 ± 2.0	6.3 ± 2.0	0.225
postoperative 2–24 h	3.2 ± 1.4	3.5 ± 1.5	3.3 ± 2.0	0.608
Postoperative 24–48 h	1.7 ± 1.0	1.9 ± 1.0	1.5 ± 1.4	0.180
Rescue analgesic requirements
postoperative 0–2 h	8 (20.0%)	11 (25.0%)	9 (22.5%)	0.861
postoperative 2–24 h	0 (0.0%)	2 (4.5%)	0 (0.0%)	0.158
Postoperative 24–48 h	1 (2.5%)	1 (2.3%)	0 (0.0%)	0.614

Data presented as mean ± SD or n (%) of patients
Group G, patients received oral gabapentin 300 mg 1 h before induction of anesthesia; Group R, patients received intravenous ramosetron 0.3 mg at the end of surgery; Group GR, patients received oral gabapentin 300 mg 1 h before induction of anesthesia and intravenous ramosetron 0.3 mg at the end of surgery; VNRS verbal numerical rating scale 0–10; 0 = no nausea, 10 = worst nausea

ISSN: 1471-2253