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Fig. 4 | BMC Anesthesiology

Fig. 4

From: Lidocaine relaxation in isolated rat aortic rings is enhanced by endothelial removal: possible role of Kv, KATP channels and A2a receptor crosstalk

Fig. 4

Concentration-response curves to lidocaine with and without the presence of specific ion channel blockers in intact isolated rat aortic rings. a In the presence of 1 mM 4-aminopyridine. b In the presence of 1 mM 5-Hydroxydecanoate. c In the presence of 10 μM glibenclamide. d In the presence of 100 μM ouabain. Relaxation is expressed as percent of maximal relaxation to 100 μM papaverine. Points represent mean ± S.E.M of aortic rings in the presence of L-NAME and indomethacin. *P < 0.05 statistical difference in responses between the presence and the absence of inhibitors on intact rings. Lidocaine concentrations are on a log scale. Total animals n = 16

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