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Table 1 Chronic morphine treatment alters baseline thermal sensitivity

From: Anti-nerve growth factor antibody attenuates chronic morphine treatment-induced tolerance in the rat

Mean paw withdrawal latencies (sec)

 

Day 1

Day 3

Day 5

Sal-Sal

8.87 ± 0.48

7.708 ± 0.29

8.498 ± 0.32

Mor-Sal

9.518 ± 0.48

7.891 ± 0.44

6.326 ± 0.36 ** ###

Mor + Anti-NGF

8.166 ± 0.42

8.042 ± 0.61

5.709 ± 0.22 ** ###

Anti-NGF-Sal

9.631 ± 0.16

9.049 ± 0.22

8.326 ± 0.15 ***

  1. Data are expressed as mean ± SEM, and refer to paw withdrawal latencies prior to Saline-Saline, Morphine-Saline, Morphine + Anti-NGF or Anti-NGF-Saline treatment on the day 1, day 3 and day 5. ** P < 0.01, *** P < 0.001 as compared to day 1 pre-treatment (baseline) of each corresponding group. ### P < 0.001 represents significant difference compared to day 5 of Sal-Sal group
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BMC Anesthesiology

ISSN: 1471-2253

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