Fig. 3
From: Anti-nerve growth factor antibody attenuates chronic morphine treatment-induced tolerance in the rat
Chronic morphine treatment increases the levels of NGF in the spinal cord as measured by ELISA (Fig. 3). The quantity of NGF protein in the lumbar sections (L4-L6) of chronic morphine treated group showed more than three-fold higher than either saline alone or anti-NGF alone treated groups. Co-administration of anti-NGF antibody significantly decreased the NGF content. No significant difference among saline, Anti-NGF and morphine + anti-NGF-treated groups was observed. Data are expressed as mean ± SEM. ** P < 0.001 compared to Saline-Saline group and ## P < 0.001compared to Morphine + anti-NGF group