Table 1 Clinicopathologic characteristics of septic patients with genetic variants in the Hypoxia-inducible factor-1α gene (SNP rs11549465)

Patients’ characteristics

 Gender (women/men; %)

37/65 (36.3/63.7)

4/18 (18.2/81.8)

1/0

0.103**

 age (years; median; Q1; Q3)^c

56 (48–66)

68 (53–72)

68

0.027*

 height (cm; median; Q1; Q3)^c

172 (165–180)

177 (167–181)

160

0.395*

 body weight (kg; median; Q1; Q3)^c

80 (68–91)

84 (72–92)

80

0.496*

 BMI (kg m-²; median; Q1; Q3)^c

26.2 (22.9–30.8)

27.9 (22.7–29.7)

31.3

0.741*

 Heart rate (min⁻¹; median, Q1; Q3)^c

100 (90–125)

107 (85–132)

101

0.870*

 Mean arterial blood pressure (mmHg; median; Q1; Q3)^c

78 (63–90)

70 (63–79)

70

0.200*

 creatinin serum concentration (mg dl⁻¹; (median; Q1;Q3)^c

1.43 (1.0–2.39)

1.71 (0.91–2.58)

2.48

0.749*

 Dialysis (yes/no; %)

67/34 (65.7/33.3)

16/6 (72.7/27.3)

0/1

0.564**

Primary diagnoses %

 Gastrointestinal disease

25 (29.8)

10 (45.5)

1

^d

 Lung disease

21 (25)

4 (18.2)

 Cardiovascular disease

7 (8.3)

3 (13.6)

 Hematooncological disease

6 (7.1)

1 (4.5)

 Urogenital cancer

6 (7.1)

1 (4.5)

 Intraabdominal pathology, other Cancer, other

19 (22.6)

3 (13.6)

Infectious variables

 White blood cell count (10⁹ l⁻¹; median; Q1; Q3)^c

14.1 (9.8–20.1)

11.2 (6.4–17.0)

18.8

0.220*

 Procalcitonin concentration (μg l⁻¹; median; Q1; Q3)^c

3.0 (1.0–19.2)

3.7 (0.6–9.2)

16.1

0.614*

 C-reactive protein concentration (g l⁻¹; median; Q1; Q3)^c

17.2 (8.8–26.3)

18 (9.7–25.0)

5.6

0.627*

Disease severity

 SAPS II^e (mean ± SD)^b

35 (27–48)

40 (33–50)

41

0.248*

 Hospital stay (d; mean ± SD)^b

23 (13–37)

21 (14–39)

67

0.729*

 30-day mortality (%)

37 (36.3)

10 (45.5)

0

0.502**