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Table 3 Circulatory treatment and postoperative outcome in patients treated with inotropes because of heart failure on weaning from CPB

From: Post hoc analysis of the glutamics–trial: intravenous glutamate infusion and use of inotropic drugs after cabg

 

Placebo n = 13

Glutamate n = 17

p-value

Inotropes (total)

100 %

100 %

1.0

Inotropic duration (hours)a

85 ± 77

34 ± 20

0.014

Number of inotropes

1.8 ± 0.7

1.3 ± 0.6

0.04

Adrenaline

85 %

88 %

1.0

Adrenalin duration (hours)a

78 ± 82

25 ± 19

0.016

Adrenalin duration (hours)b

92 ± 82

28 ± 17

0.007

Average max dosage μg/kg/minb

0.031 ± 0.012

0.029 ± 0.030

0.73

Milrinone

54 %

35 %

0.46

Milrinone duration (hours)a

33 ± 52

9 ± 14

0.09

Milrinone duration (hours)b

60 ± 60

27 ± 8

0.20

Average max dosage μg/kg/minb

0.38 ± 0.15

0.36 ± 0.02

0.78

Noradrenaline

85 %

59 %

0.23

Average max dosage μg/kg/mina

0.089 ± 0.096

0.034 ± 0.033

0.03

Average max dosage μg/kg/minb

0.106 ± 0.095

0.058 ± 0.022

0.14

IABP

31 %

0 %

0.03

Postoperative outcome

   

 Time on ventilator (hours)

109 ± 192

6 ± 3

0.033

 Time on ventilator >48 h

46 %

0.0 %

0.003

 ICU stay (hours)

150 ± 186

45 ± 38

0.031

 Severe circulatory failure

61.5 %

11.8 %

0.007

 Stroke within 24 h

0.0 %

0.0 %

1.0

 Cardiac mortality

15.4 %

5.9 %

0.56

 30 day mortality

15.4 %

5.9 %

0.56

 Hospital mortality

15.4 %

5.9 %

0.56

  1. IABP intra-aortic balloon pump, ICU intensive care unit
  2. aaverage for all patients treated with inotropes
  3. baverage for patients treated with specific drug