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Table 2 Circulatory treatment and postoperative outcome in all patients treated with inotropes

From: Post hoc analysis of the glutamics–trial: intravenous glutamate infusion and use of inotropic drugs after cabg

 

Placebo n = 77

Glutamate n = 94

p-value

Circulatory treatment

   

 Inotropes (total)

100 %

100 %

 

 Inotropes duration (hours)

38 ± 46

29 ± 30

0.14

 Number of inotropes

1.4 ± 0.6

1.3 ± 0.6

0.45

 Adrenaline

63.6 %

70.2 %

0.41

 Adrenaline duration (hours)a

28 ± 49

17 ± 25

0.049

 Adrenaline duration (hours)b

44 ± 55

24 ± 27

0.01

 Average max dosage μg/kg/minb

0.028 ± 0.016

0.028 ± 0.020

0.94

 Milrinone

50.6 %

39.4 %

0.16

 Milrinone duration (hours)a

14 ± 25

9 ± 19

0.14

 Milrinone duration (hours)b

27 ± 30

22 ± 25

0.44

 Average max dosage μg/kg/minb

0.40 ± 0.14

0.36 ± 0.12

0.28

 Noradrenaline

71.4 %

70.2 %

1.0

 Average max dosage μg/kg/mina

0.084 ± 0.093

0.068 ± 0.089

0.24

 Average max dosage μg/kg/minb

0.118 ± 0.090

0.097 ± 0.092

0.20

 IABP

5.2 %

0 %

0.04

Postoperative outcome

   

 Time on ventilator (hours)

34 ± 95

26 ± 74

0.54

 ICU stay (hours)

63 ± 98

59 ± 78

0.79

 Severe circulatory failure

17.5 %

6.2 %

0.03

 Stroke within 24 h

2.6 %

3.2 %

1.0

 Cardiac mortality

2.6 %

1.1 %

0.59

 30 day mortality

1.3 %

2.1 %

1.0

 Hospital mortality

2.6 %

3.2 %

1.0

  1. IABP intra-aortic balloon pump, ICU intensive care unit
  2. aaverage for all patients treated with inotropes
  3. baverage for patients treated with specific drug