Skip to main content

Table 1 Preoperative, intraoperative and postoperative data in patients undergoing isolated CABG for acute coronary syndrome in the GLUTAMICS-trial

From: Post hoc analysis of the glutamics–trial: intravenous glutamate infusion and use of inotropic drugs after cabg

 

Placebo n = 413

Glutamate n = 411

p-value

Preoperative data

   

 Age (years)

68 ± 9

68 ± 9

0.30

 Female

18.9 %

17.5 %

0.65

 Weight (kg)

83 ± 15

81 ± 14

0.25

 Length (cm)

173 ± 8

173 ± 8

0.59

 BMI (kg/m2)

27 ± 4

27 ± 4

0.10

 B-Hb (g/l)

137 ± 14

137 ± 14

0.68

 p-Creatinine (μmol/l)

97 ± 29

98 ± 27

0.60

 Hypertension

60 %

56 %

0.29

 COPD

5.1 %

7.9 %

0.09

 Diabetes

26 %

24 %

0.50

 Extra-cardiac arterial disease

9 %

14 %

0.049

 CCS class IV angina

56 %

55 %

0.73

 Left main stem stenosis

34 %

42 %

0.02

 Myocardial Infarct < 24 h

1.2 %

0.2 %

0.22

 Moderate-Severe LV-dysfunction

18.6 %

18.0 %

0.86

 EuroSCORE

4.9 ± 2.7

5.2 ± 2.7

0.10

Intraoperative data

   

 Number of bypasses

3.9 ± 1.1

4.1 ± 1.0

0.18

 Cross-clamp time (min)

52 ± 18

51 ± 18

0.51

 CPB time (min)

80 ± 25

81 ± 28

0.61

Indications for inotropes

   

 Preemptively before weaning from CPB

9.0 %

9.7 %

0.81

 LV-failure at weaning from CPB

3.4 %

4.4 %

0.48

 Late onset cardiac failure

1.9 %

1.9 %

1.0

 Cardiac failure postoperatively (total)

5.3 %

6.3 %

0.54

 Late circulatory failure non-cardiac

3.4 %

1.5 %

0.11

 Other

0.9 %

5.4 %

0.001

Circulatory treatment

   

 Inotropes (total)

18.6 %

22.9 %

0.15

 Adrenaline

11.9 %

16.1 %

0.09

 Milrinone

9.4 %

9.0 %

0.90

 Levosimendane

3.6 %

3.4 %

1.0

 Dopamine

1.7 %

2.7 %

0.35

 Intra-aortic balloon pump

1.2 %

0 %

0.06

Postoperative outcome

   

 Time on ventilator (h)

13 ± 54

10 ± 37

0.35

 ICU stay (h)

31 ± 58

30 ± 52

0.77

 Severe circulatory failure

3.9 %

1.5 %

0.049

 Stroke within 24 (h)

1.5 %

1.0 %

0.53

 Cardiac mortality

0.7 %

0.2 %

0.62

 30 days mortality

1.0 %

0.7 %

0.71

 Hospital mortality

1.2 %

1.2 %

0.74

Postoperative outcome

   

 Time on ventilator (h)

13 ± 54

10 ± 37

0.35

 ICU stay (h)

31 ± 58

30 ± 52

0.77

 Severe circulatory failure

3.9 %

1.5 %

0.049

 Stroke within 24 (h)

1.5 %

1.0 %

0.53

  1. BMI body mass index, COPD chronic obstructive pulmonary disease, LV left ventricular, CPB cardiopulmonary bypass, ICU, intensive care unit