Placebo n = 413 | Glutamate n = 411 | p-value | |
---|---|---|---|
Preoperative data | |||
Age (years) | 68 ± 9 | 68 ± 9 | 0.30 |
Female | 18.9 % | 17.5 % | 0.65 |
Weight (kg) | 83 ± 15 | 81 ± 14 | 0.25 |
Length (cm) | 173 ± 8 | 173 ± 8 | 0.59 |
BMI (kg/m2) | 27 ± 4 | 27 ± 4 | 0.10 |
B-Hb (g/l) | 137 ± 14 | 137 ± 14 | 0.68 |
p-Creatinine (μmol/l) | 97 ± 29 | 98 ± 27 | 0.60 |
Hypertension | 60 % | 56 % | 0.29 |
COPD | 5.1 % | 7.9 % | 0.09 |
Diabetes | 26 % | 24 % | 0.50 |
Extra-cardiac arterial disease | 9 % | 14 % | 0.049 |
CCS class IV angina | 56 % | 55 % | 0.73 |
Left main stem stenosis | 34 % | 42 % | 0.02 |
Myocardial Infarct < 24 h | 1.2 % | 0.2 % | 0.22 |
Moderate-Severe LV-dysfunction | 18.6 % | 18.0 % | 0.86 |
EuroSCORE | 4.9 ± 2.7 | 5.2 ± 2.7 | 0.10 |
Intraoperative data | |||
Number of bypasses | 3.9 ± 1.1 | 4.1 ± 1.0 | 0.18 |
Cross-clamp time (min) | 52 ± 18 | 51 ± 18 | 0.51 |
CPB time (min) | 80 ± 25 | 81 ± 28 | 0.61 |
Indications for inotropes | |||
Preemptively before weaning from CPB | 9.0 % | 9.7 % | 0.81 |
LV-failure at weaning from CPB | 3.4 % | 4.4 % | 0.48 |
Late onset cardiac failure | 1.9 % | 1.9 % | 1.0 |
Cardiac failure postoperatively (total) | 5.3 % | 6.3 % | 0.54 |
Late circulatory failure non-cardiac | 3.4 % | 1.5 % | 0.11 |
Other | 0.9 % | 5.4 % | 0.001 |
Circulatory treatment | |||
Inotropes (total) | 18.6 % | 22.9 % | 0.15 |
Adrenaline | 11.9 % | 16.1 % | 0.09 |
Milrinone | 9.4 % | 9.0 % | 0.90 |
Levosimendane | 3.6 % | 3.4 % | 1.0 |
Dopamine | 1.7 % | 2.7 % | 0.35 |
Intra-aortic balloon pump | 1.2 % | 0 % | 0.06 |
Postoperative outcome | |||
Time on ventilator (h) | 13 ± 54 | 10 ± 37 | 0.35 |
ICU stay (h) | 31 ± 58 | 30 ± 52 | 0.77 |
Severe circulatory failure | 3.9 % | 1.5 % | 0.049 |
Stroke within 24 (h) | 1.5 % | 1.0 % | 0.53 |
Cardiac mortality | 0.7 % | 0.2 % | 0.62 |
30 days mortality | 1.0 % | 0.7 % | 0.71 |
Hospital mortality | 1.2 % | 1.2 % | 0.74 |
Postoperative outcome | |||
Time on ventilator (h) | 13 ± 54 | 10 ± 37 | 0.35 |
ICU stay (h) | 31 ± 58 | 30 ± 52 | 0.77 |
Severe circulatory failure | 3.9 % | 1.5 % | 0.049 |
Stroke within 24 (h) | 1.5 % | 1.0 % | 0.53 |