Fig. 3
From: shRNA mediated knockdown of Nav1.7 in rat dorsal root ganglion attenuates pain following burn injury
The change of hypersensitivity to heat and mechanical stimuli on burn injury model of rats after injected with LV-SCN9AsiRNA-GFP and LV-NC-GFP. (a) Response thresholds to mechanical stimuli in the von Frey test are strongly increased after treated with LV-SCN9AsiRNA-GFP and unchanged in LV-NC-GFP-treated animals. (b) And there was no difference of mechanical hypersensitivity between two groups on the contralateral side. (*p < 0.05, **p < 0.01, ***P <0.001, NS: not statistically significant; n =18 rats/group). (c) Response thresholds to radiant heat stimuli (Hargreaves’ test) are obviously revived on the ipsilateral side after treated with LV-SCN9AsiRNA-GFP while LV-NC-GFP didn't. (d) Heat hypersensitivity has no difference between two groups on the contralateral side. (*p < 0.05, **p < 0.01, ***P <0.001, NS: not statistically significant; versus the LV-NC-GFP group; n =18 rats/group.)