Fig. 1
From: shRNA mediated knockdown of Nav1.7 in rat dorsal root ganglion attenuates pain following burn injury
Bury injury causes the hypersensitivity to heat and mechanical stimuli in rat. (a) Response thresholds to mechanical stimuli in the von Frey test are strongly decreased on the ipsilateral side in burn model animals and unchanged in sham-treated animals. (b) neither on the contralateral side. Mechanical hypersensitivity resolves within 3 weeks. (*p < 0.05, **p < 0.01, ***p < 0.001, NS: not statistically significant; n =16 rats/group.) (c) Response thresholds to radiant heat stimuli (Hargreaves’test) are strongly decreased on the ipsilateral side in burn model animals and unchanged in sham-treated animals. (d) And there was no change on the contralateral side. Heat hypersensitivity is present at the earliest time point assessed and resolves within 3 weeks. (*p < 0.05, **p < 0.01, ***p < 0.001vs sham group; n=16 rats/ group.)