Biological inflammatory markers mediate the effect of preoperative pain-related behaviours on postoperative analgesics requirements

Table 2 Paths coefficients and statistics of the two-mediator model (see Fig. 2 lower panel)

Paths	SPS - > NLR	SPS - > HADS	NLR - > DU	HADS - > DU	SPS - > UD	SPS - > NLR - > UD	SPS- > HADS - > UD	SPS - > UD sum of effects	HADS < − > NLR Interaction among mediators
Symbols	a₁	a₂	b₁	b₂	c'	a₁ x b₁	a₂ x b₂	(a₁ x b₁₎+ (a₂ x b₂₎	m2 < − > m1	Contrast^a
Coefficient	−0.180	1.634	−1.243	0.102	0.097	0.224	0.166	0.390	−0.093	0.057
S.E.	0.038	0.247	0.365	0.063	0.361	0.079	0.119	0.196	0.435	0.047
t statistic	−4.774	6.612	−3.403	1.608	0.269	2.819	1.401	1.985	−0.214	1.219
P value	< 0.001	< 0.001	0.001	0.108	0.788	0.005	0.161	0.047	0.831	0.223

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