From: Temporal trends in the systemic inflammatory response syndrome, sepsis, and medical coding of sepsis
Variable | Comment | Type |
---|---|---|
SIRS | Uses the Surviving Sepsis Campaign [3] definition of the systemic inflammatory response syndrome. At least two vital sign measurements were required outside the range on a given calendar day (for each of the three vital signs: temperature, heart rate, and respiratory rate). | Patient-level |
Sepsis | Defined by one of the following ICD-9 codes: 995 · 91, 995 · 92, 785 · 52 | Administrative |
Sepsis (Angus) | Defined using the ICD-9 codes outlined in Angus et al., Crit Care Med. 2001;29 (7):1303–1310 | Administrative |
Sepsis (Dombrovskiy) | Defined using the ICD-9 codes outlined in Dombrovskiy et al., Crit Care Med. 2007;35 (5):1244–1250 | Administrative |
Sepsis | SIRS plus bacteremia (within a calendar day of SIRS event) | Patient-level |
Severe sepsis | SIRS plus Hypotension (Systolic blood pressure <90 mmHg, occurring within a calendar day of the SIRS event) + Bacteremia | Patient-level |
SIRS plus hypotension | SIRS plus Hypotension | Patient-level |
Any SIRS | SIRS on a single calendar day during the hospitalization | Patient-level |
Multi-day SIRS | SIRS on 3 or more calendar days | Patient-level |
Bacteremia | First positive blood culture within a calendar day of a SIRS event. Common skin contaminants were excluded (Coagulase-negative staphylococci, Micrococcus spp, Propionibacterium acnes, Bacillus spp, Corynebacterium spp.). | Patient-level |