Table 2 Parameter estimates (mean (CV%)) of the final population PK model for paracetamol and its metabolites in women at delivery, early postpartum, late postpartum or healthy volunteers, with or without oral contraceptives (OC). For ClPG, V1 and Q1 both the final value and the equation is presented in which values in italic represent the value for the standard population for that parameter
From: Paracetamol pharmacokinetics and metabolism in young women
Parameter | Mean | Bootstrap mean | ||
|---|---|---|---|---|
final model | (CV%) | (CV%) | ||
Fixed effects | ||||
At delivery | postpartum, early | postpartum, late + healthy volunteers | ||
10 weeks later | ||||
CLPG (L/h) | 7.33 (8.3) | 2.02 (11.1) | ||
0.55 (18.5) × 7.33 = 4.0 | 7.41 (9.7) | |||
OC: 1.46 (12.5) × 4.0 = 5.8 | OC:1.46 × 7.33 = 10.7 | 0.56 (19.5) | ||
2.03(8.8) × 7.33 = 14.9 | 1.48 (10.8) | |||
CLPS (L/h) | 3.86 (5.5) | 3.86 (5.5) | 3.82 (5.6) | |
Preterm = 5.61 (7.9) | 5.65 (8.4) | |||
CLPU (L/h) | 0.93 (6.3) + 0.0053 (28.2) × (UP-100) | 0.94 (6.5) | ||
0.0054 (29.8) | ||||
V1 (L) | 1.86 (6.3) × 18.5 = | 18.5 (7.9) | 1.83 (6.4) | |
34.4 | 18.5 (7.4) | |||
V2 (L) | 19.7 (33.6) | 22.3 (37.9) | ||
V8 (L) | 23.9 (5.4) | 23.9 (5.0) | ||
Q (L/h) | 1.29 (15.0) × (BW/70) | 1.34 (14.2) | ||
Q1 (L/h) | 61.1 (6.8) | 0.13 (17.9) × 61.1 = 7.9 | 61.1 (6.8) | 61.6 (6.3) |
0.13 (19.2) | ||||
MF | 4.62 (11.8) | 4.73 (10.7) | ||
Interindividual variability | ||||
ωCLpg2 | 0.12 (23.0) | 0.12 (23.2) | ||
ωV12 | 0.09 (24.1) | 0.08 (24.4) | ||
ωCLpu2 | 0.12 (61.6) | 0.11 (58.7) | ||
Residual error | ||||
σ2 (P plasma) | 0.07 (12.8) | 0.07 (13.8) | ||
σ2 (P G) | 0.29 (48.6) | 0.29 (46.0) | ||
σ2 (P S) | 0.15 (26.1) | 0.14 (23.5)) | ||
σ2 (P u) | 0.15 (20.4) | 0.15 (17.9) | ||
σ2 (P plasma) Gregoire [15] | 0.02 (21.6) | 0.02 (19.4) | ||
σ2 (P plasma), additive Gregoire [15] | 0.016 (64.4) | 0.016 (61.8) | ||
Performance measures | ||||
−2LL | 5286.743 | 5241.994 (3.8) | ||