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Table 1 Clinical characteristics of the study population. Data are provided as by mean and standard deviation or incidence

From: Paracetamol pharmacokinetics and metabolism in young women

 

Pregnancy and postpartum

Healthy volunteers

at delivery

postpartum, early

postpartum, late

no oral contraceptives

contraceptives

Number of cases

47

8 (8 of 47)

7 (7 of 8)

8

14

Plasma samples, number and time

275, 0–24 h

32, 0–6 h

28, 0–6 h

32, 0–6 h

448, 0–24 h

Urine collections, number and time

78, 0–24 h

8, 0–6 h

7, 0–6 h

8, 0–6 h

n.a.

Age (years)

30.9 (5.3)

32.1 (3.9)

32.9 (4.1)

31.1 (4.3)

23.5 (4.0)

Body weight (kg)

79.7 (12.9)

68.8 (11.2)

67.1 (13.5)

63.9 (6.6)

59.8 (8.9)

Body surface area (m2)

1.93 (0.19)

1.79 (0.17)

1.76 (0.2)

1.74 (0.1)

1.66 (0.14)

<37 weeks, at delivery

21/47

3/8

3/7

n.a.

n.a.

37–41 weeks, at delivery

26/47

5/8

4/7

n.a.

n.a.

Oestradiol (pg.ml−1)

4 833 (3 555)

86 (30)

75 (65)

79 (70)

n.a.

Progesterone (ng.ml−1)

118 (95)

1.1 (0.55)

0.4 (0.2)

2.8 (3.9)

n.a.

Follicular/luteal phase (number, each)

n.a.

3/0

5/0

6/2

n.a.

Oral contraceptives (number/total)

n.a.

4/8

2/7

0

13/14