From: Paracetamol pharmacokinetics and metabolism in young women
Pregnancy and postpartum | Healthy volunteers | ||||
---|---|---|---|---|---|
at delivery | postpartum, early | postpartum, late | no oral contraceptives | contraceptives | |
Number of cases | 47 | 8 (8 of 47) | 7 (7 of 8) | 8 | 14 |
Plasma samples, number and time | 275, 0–24 h | 32, 0–6 h | 28, 0–6 h | 32, 0–6 h | 448, 0–24 h |
Urine collections, number and time | 78, 0–24 h | 8, 0–6 h | 7, 0–6 h | 8, 0–6 h | n.a. |
Age (years) | 30.9 (5.3) | 32.1 (3.9) | 32.9 (4.1) | 31.1 (4.3) | 23.5 (4.0) |
Body weight (kg) | 79.7 (12.9) | 68.8 (11.2) | 67.1 (13.5) | 63.9 (6.6) | 59.8 (8.9) |
Body surface area (m2) | 1.93 (0.19) | 1.79 (0.17) | 1.76 (0.2) | 1.74 (0.1) | 1.66 (0.14) |
<37 weeks, at delivery | 21/47 | 3/8 | 3/7 | n.a. | n.a. |
37–41 weeks, at delivery | 26/47 | 5/8 | 4/7 | n.a. | n.a. |
Oestradiol (pg.ml−1) | 4 833 (3 555) | 86 (30) | 75 (65) | 79 (70) | n.a. |
Progesterone (ng.ml−1) | 118 (95) | 1.1 (0.55) | 0.4 (0.2) | 2.8 (3.9) | n.a. |
Follicular/luteal phase (number, each) | n.a. | 3/0 | 5/0 | 6/2 | n.a. |
Oral contraceptives (number/total) | n.a. | 4/8 | 2/7 | 0 | 13/14 |