Fig. 2

Diagnostics plots for the final PK model for a women at delivery, b women in early postpartum and c women in late postpartum and d healthy volunteers including observations vs individual predictions (left) and observations vs population predictions (right) for paracetamol concentrations in plasma (circle, upper panels) and amount of paracetamol-glucuronide (diamond), paracetamol-sulphate (triangle), and unchanged paracetamol (square) in urine (lower panels) as paracetamol equivalents with x = y identity line. The solid symbols indicate women on contraceptives, the open symbols women with no contraceptives. In panel c the group of healthy volunteers on contraceptives (n = 14, Gregoire) are distinguished from women in late postpartum by a triangle down, the healthy volunteers with no contraceptives (n = 8) by symbols plus (circle plus; diamond plus, triangle box and square plus)