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Table 2 Summary of key results from included studies evaluating pharmacological interventions in patients undergoing radical prostatectomy

From: Optimal pain management for radical prostatectomy surgery: what is the evidence?

Reference Intervention studied Pain scores Supplementary analgesia Time to first analgesic request
Non-steroidal Anti-Inflammatory Drugs (NSAIDs)
 Mazaris 2008 [33] lornoxicam versus paracetamol ↓at rest NS -
 Ormiston 1981 [34] aspirin versus tiaprofenic acid NS at rest - -
 Bilgin 2011 [14] Diclofenac, IM versus placebo ↓↓ at rest ↓↓ -
 Dirkmann 2015 [55] Parecoxib versus placebo ↓↓ ↓↓ -
Cyclo-oxygenase-2 Selective Inhibitors
 Huang 2001 [29] rofecoxib versus placebo NS at rest NS -
 Chelly 2011 [17] celecoxib versus placebo ↓at rest -
Lidocaine Infusion
 Groudine 1998 [21] lidocaine versus placebo ↓↓ at rest NS -
 Lauwick 2009 [44] lidocaine versus placebo* NS at rest -
Opioids
 Larijani 2004 [48] morphine versus placebo ↓↓ at rest - NS
 Gaitini 1996 [19] buprenorphine versus morphine NS at rest - -
Topical Administration
 Habib 2008 [24] nicotine versus placebo NS at rest and on coughing ↓↓ -
 Habib 20 09 [23] lidocaine versus placebo ↓↓ at rest and on coughing NS -
Analgesic Adjuncts
a2 agonists     
 Mayson 2000 [32] clonidine versus placebo NS at rest and on coughing NS -
Muscarinic receptor antagonists
 Tauzin-Fin 2007 [40] oxybutynin versus placebo ↓↓ at rest ↓↓ -
 Lukasewycz 20 1 0 [47] belladonna and opium versus placebo* ↓ at rest NS on movement NS  
N-methyl-D-aspartic acid (NMDA) antagonists
 Tauzin-Fin 2006 [40] magnesium versus placebo NS at rest ↓↓ NS
 Katz 2004 [30] ketamine versus placebo NS at rest NS -
 Snijdelaar 2004a [38] ketamine versus placebo ↓↓ at rest NS on movement ↓↓ -
 Snijdelaar 2004b [39] amantadine versus placebo NS at rest ↓↓ -
Melatonin
 Borazan 2010 [15] melatonin versus placebo ↓↓ at rest ↓↓ -
Gabapentin
 Deniz 2012 [62] Gabapentin versus placebo ↓↓ at rest for 2 h postop NS -