Table 2 Summary of key results from included studies evaluating pharmacological interventions in patients undergoing radical prostatectomy

 Mazaris 2008 [33]

lornoxicam versus paracetamol

↓at rest

NS

-

 Ormiston 1981 [34]

aspirin versus tiaprofenic acid

NS at rest

-

-

 Bilgin 2011 [14]

Diclofenac, IM versus placebo

↓↓ at rest

↓↓

-

 Dirkmann 2015 [55]

Parecoxib versus placebo

↓↓

↓↓

-

 Huang 2001 [29]

rofecoxib versus placebo

NS at rest

NS

-

 Chelly 2011 [17]

celecoxib versus placebo

↓at rest

↓

-

 Groudine 1998 [21]

lidocaine versus placebo

↓↓ at rest

NS

-

 Lauwick 2009 [44]

lidocaine versus placebo*

NS at rest

↓

-

 Larijani 2004 [48]

morphine versus placebo

↓↓ at rest

-

NS

 Gaitini 1996 [19]

buprenorphine versus morphine

NS at rest

-

-

 Habib 2008 [24]

nicotine versus placebo

NS at rest and on coughing

↓↓

-

 Habib 20 09 [23]

lidocaine versus placebo

↓↓ at rest and on coughing

NS

-

a2 agonists

 Mayson 2000 [32]

clonidine versus placebo

NS at rest and on coughing

NS

-

 Tauzin-Fin 2007 [40]

oxybutynin versus placebo

↓↓ at rest

↓↓

-

 Lukasewycz 20 1 0 [47]

belladonna and opium versus placebo*

↓ at rest NS on movement

NS

 Tauzin-Fin 2006 [40]

magnesium versus placebo

NS at rest

↓↓

NS

 Katz 2004 [30]

ketamine versus placebo

NS at rest

NS

-

 Snijdelaar 2004a [38]

ketamine versus placebo

↓↓ at rest NS on movement

↓↓

-

 Snijdelaar 2004b [39]

amantadine versus placebo

NS at rest

↓↓

-

 Borazan 2010 [15]

melatonin versus placebo

↓↓ at rest

↓↓

-

 Deniz 2012 [62]

Gabapentin versus placebo

↓↓ at rest for 2 h postop

NS

-