Table 1 Basic Information of the 15 studies included in the meta-analysis

Gravel et al. [10]

Canada

CABG (on-pump and off-pump)

15/15

4 % sevoflurane + 0.5 μg/kg sufentanil

0.5-2MAC sevoflurane + 0.5 μg/kg/h sufentanil

1 mg midazolam + 0.5 μg/kg sufentanil

40-150 μg/kg/min propofol + 0.5 μg/kg/h sufentanil

De Hert et al. [11]

Belgium

CABG (on-pump)

10/10

4 % sevoflurane + 0.4 μg/kg/min remifentanil

0.5–2 % sevoflurane + 0.3–0.6 μg/kg/min remifentanil

2 mg/ml propofol + 0.4 μg/kg/min remifentanil

2-4 mg/ml propofol + 0.3-0.6 μg/kg/min remifentanil

Conzen et al. [12]

Germany

CABG (off-pump)

10/10

0.3 mg/kg etomidate

2 % sevoflurane

2 μg/ml propofol

2-3 μg/ml propofol

De Hert et al. [13]

Belgium

CABG (on-pump)

15/15

2–8 % sevoflurane + 0.4 μg/kg/min remifentanil

0.5–2%sevoflurane + 0.3–0.6 μg/kg/min remifentanil

2 μg/ml propofol + 0.4 μg/kg/min remifentanil

2-4 μg/ml propofol + 0.3-0.6 μg/kg/min remifentanil

De Hert et al. [14]

Belgium

CABG (on-pump)

80/80

0.1 mg/kg midazolam + 0.4 μg/kg/min remifentanil

0.5–2 % sevoflurane + 0.2–0.4 μg/kg/min remifentanil

2 μg/mlpropofol + 0.4 μg/kg/min remifentanil

2-4 μg/ml propofol + 0.2-0.4 μg/kg/min remifentanil

Parker et al. [15]

Australia

CABG (on-pump)

118/118

10 μg/kg fentanyl + 0.1 mg/kg diazepam + 0.15 mg/kg pancuronium bromide

1–4 % sevoflurane

10 μg/kg fentanyl + 0.1 mg/kg diazepam + 0.15 mg/kg pancuronium bromide

1-8 μg/ml propofol

Kawamura et al. [16]

Japan

CABG (on-pump)

13/10

10 μg/kg fentanyl + 2–3 mg midazolam

0.5 %-1 % sevoflurane + 30 μg/kg fentanyl

10 μg/kg fentanyl + 2–3 mg midazolam

2-8 mg/kg/h propofol + 30 μg/kg fentanyl

Cromheecke et al. [17]

Belgium

AVR

15/15

0.5–1 % sevoflurane + 0.4 μg/kg/min remifentanil

0.5–1 % sevoflurane + 0.2–0.4 μg/kg/min remifentanil

2 μg/ml propofol + 0.4 μg/kg/min remifentanil

2-4 μg/mlpropofol + 0.2-0.4 μg/kg/min remifentanil

Lorsomradee et al.[18]

Belgium

CABG (on-pump)

160/160

sevoflurane + 0.2–0.4 μg/kg/min remifentanil

0.5–2 % sevoflurane + 0.2–0.4 μg/kg/min remifentanil

2 μg/ml propofol + 0.2-0.4 μg/kg/min remifentanil

2-4 μg/ml propofol + 0.2-0.4 μg/kg/min remifentanil

Law-Koune et al. [19]

France

CABG (off-pump)

9/9

8 % sevoflurane + 2 ng/mL remifentanil

sevoflurane(BIS 40–60) + remifentanil

2 μg/ml propofol + 2 ng/mL remifentanil

propofol(BIS 40–60) + remifentanil

Lucchinetti et al. [20]

Switzerland

CABG (off-pump)

10/10

fentanyl + midazolam

sevoflurane + fentanyl + midazolam

fentanyl + midazolam

propofol + fentanyl + midazolam

Yildirim et al. [21]

Turkey

CABG (on-pump)

20/20

2–8 % sevoflurane + 0.4 μg/kg/min remifentanil

0.5–2 % sevoflurane + 0.3–0.6 μg/kg/min remifentanil

0.2 μg/ml propofol + 0.4 μg/kg/min remifentanil

2-4 mg/mlpropofol + 0.3-0.6 μg/kg/min remifentanil

Ballester et al. [22]

Spain

CABG (off-pump)

18/20

0.1 mg/kg midazolam + 2–4 μg/kg fentanyl + 0.3 mg/kg etomidate

1.5–2.5 % sevoflurane

0.1 mg/kg midazolam + 2–4 μg/kg fentanyl + 0.3 mg/kg etomidate

6-8 mg/kg/h propofol

Jovic et al. [23]

Serbian

AVR

11/11

0.3 mg/kg midazolam + 0.7–1 mcg/kg sufentanil

0.1–0.2 mcg/kg/h sevoflurane

1–1.5 mg/kg propofol + 0.7–1 mcg/kg sufentanil

6-10 mg/kg/h propofol + 0.1-0.2 mcg/kg/h sufentanil

Suryaprakash et al. [24]

India

CABG (off-pump)

48/39

5–10 μg/ kg fentanyl + 0.02 mg/kg midazolam

1–2 % sevoflurane + 1 μg/kg/h fentanyl

5–10 μg/ kg fentanyl + 0.02 mg/kg midazolam

2-4 mg/kg/h propofol + 1 μg/kg/h fentanyl