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Table 1 Basic Information of the 15 studies included in the meta-analysis

From: Meta-analysis of the cardioprotective effect of sevoflurane versus propofol during cardiac surgery

Study Country Surgery Number of cases (Sevoflurane/propofol, n) Anesthesia
Sevoflurane group Propofol group
Induction Maintenance Induction Maintenance
Gravel et al. [10] Canada CABG (on-pump and off-pump) 15/15 4 % sevoflurane + 0.5 μg/kg sufentanil 0.5-2MAC sevoflurane + 0.5 μg/kg/h sufentanil 1 mg midazolam + 0.5 μg/kg sufentanil 40-150 μg/kg/min propofol + 0.5 μg/kg/h sufentanil
De Hert et al. [11] Belgium CABG (on-pump) 10/10 4 % sevoflurane + 0.4 μg/kg/min remifentanil 0.5–2 % sevoflurane + 0.3–0.6 μg/kg/min remifentanil 2 mg/ml propofol + 0.4 μg/kg/min remifentanil 2-4 mg/ml propofol + 0.3-0.6 μg/kg/min remifentanil
Conzen et al. [12] Germany CABG (off-pump) 10/10 0.3 mg/kg etomidate 2 % sevoflurane 2 μg/ml propofol 2-3 μg/ml propofol
De Hert et al. [13] Belgium CABG (on-pump) 15/15 2–8 % sevoflurane + 0.4 μg/kg/min remifentanil 0.5–2%sevoflurane + 0.3–0.6 μg/kg/min remifentanil 2 μg/ml propofol + 0.4 μg/kg/min remifentanil 2-4 μg/ml propofol + 0.3-0.6 μg/kg/min remifentanil
De Hert et al. [14] Belgium CABG (on-pump) 80/80 0.1 mg/kg midazolam + 0.4 μg/kg/min remifentanil 0.5–2 % sevoflurane + 0.2–0.4 μg/kg/min remifentanil 2 μg/mlpropofol + 0.4 μg/kg/min remifentanil 2-4 μg/ml propofol + 0.2-0.4 μg/kg/min remifentanil
Parker et al. [15] Australia CABG (on-pump) 118/118 10 μg/kg fentanyl + 0.1 mg/kg diazepam + 0.15 mg/kg pancuronium bromide 1–4 % sevoflurane 10 μg/kg fentanyl + 0.1 mg/kg diazepam + 0.15 mg/kg pancuronium bromide 1-8 μg/ml propofol
Kawamura et al. [16] Japan CABG (on-pump) 13/10 10 μg/kg fentanyl + 2–3 mg midazolam 0.5 %-1 % sevoflurane + 30 μg/kg fentanyl 10 μg/kg fentanyl + 2–3 mg midazolam 2-8 mg/kg/h propofol + 30 μg/kg fentanyl
Cromheecke et al. [17] Belgium AVR 15/15 0.5–1 % sevoflurane + 0.4 μg/kg/min remifentanil 0.5–1 % sevoflurane + 0.2–0.4 μg/kg/min remifentanil 2 μg/ml propofol + 0.4 μg/kg/min remifentanil 2-4 μg/mlpropofol + 0.2-0.4 μg/kg/min remifentanil
Lorsomradee et al.[18] Belgium CABG (on-pump) 160/160 sevoflurane + 0.2–0.4 μg/kg/min remifentanil 0.5–2 % sevoflurane + 0.2–0.4 μg/kg/min remifentanil 2 μg/ml propofol + 0.2-0.4 μg/kg/min remifentanil 2-4 μg/ml propofol + 0.2-0.4 μg/kg/min remifentanil
Law-Koune et al. [19] France CABG (off-pump) 9/9 8 % sevoflurane + 2 ng/mL remifentanil sevoflurane(BIS 40–60) + remifentanil 2 μg/ml propofol + 2 ng/mL remifentanil propofol(BIS 40–60) + remifentanil
Lucchinetti et al. [20] Switzerland CABG (off-pump) 10/10 fentanyl + midazolam sevoflurane + fentanyl + midazolam fentanyl + midazolam propofol + fentanyl + midazolam
Yildirim et al. [21] Turkey CABG (on-pump) 20/20 2–8 % sevoflurane + 0.4 μg/kg/min remifentanil 0.5–2 % sevoflurane + 0.3–0.6 μg/kg/min remifentanil 0.2 μg/ml propofol + 0.4 μg/kg/min remifentanil 2-4 mg/mlpropofol + 0.3-0.6 μg/kg/min remifentanil
Ballester et al. [22] Spain CABG (off-pump) 18/20 0.1 mg/kg midazolam + 2–4 μg/kg fentanyl + 0.3 mg/kg etomidate 1.5–2.5 % sevoflurane 0.1 mg/kg midazolam + 2–4 μg/kg fentanyl + 0.3 mg/kg etomidate 6-8 mg/kg/h propofol
Jovic et al. [23] Serbian AVR 11/11 0.3 mg/kg midazolam + 0.7–1 mcg/kg sufentanil 0.1–0.2 mcg/kg/h sevoflurane 1–1.5 mg/kg propofol + 0.7–1 mcg/kg sufentanil 6-10 mg/kg/h propofol + 0.1-0.2 mcg/kg/h sufentanil
Suryaprakash et al. [24] India CABG (off-pump) 48/39 5–10 μg/ kg fentanyl + 0.02 mg/kg midazolam 1–2 % sevoflurane + 1 μg/kg/h fentanyl 5–10 μg/ kg fentanyl + 0.02 mg/kg midazolam 2-4 mg/kg/h propofol + 1 μg/kg/h fentanyl
  1. CABG coronary artery bypass graphing, AVR aortic valve replacement
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