Polymorphisms on PAI-1 and ACE genes in association with fibrinolytic bleeding after on-pump cardiac surgery

BMC Anesthesiology

Table 2 PAI-1 -844 A/G and ACE Intron 16 I/D gene polymorphisms related to markers of fibrinolysis. Plasma concentrations of PAI-1 preoperatively – and of t-PA/PAI-1 complex and D-dimer postoperatively after on-pump cardiac surgery

Genetic polymorphism	n	PAI-1, ng/mL, preoperatively	t-PA/PAI-1, ng/mL, 24 h postoperatively	D-dimer, ng/mL 0 h	D-dimer, ng/mL 6 h	D-dimer, ng/mL 24 h
PAI-1 -844 A/G
A/A	23	28 ± 12*	3.8 ± 1.8	251 ± 170	289 ± 210	234 ± 187
A/G	38	24 ± 13	3.6 ± 2.1	312 ± 213	312 ± 200	184 ± 129*
G/G	22	18 ± 12*	3.4 ± 2.4	287 ± 255	255 ± 203	267 ± 168*
P value		0.004	NS	NS	NS	0.04
ACE intron 16 I/D
D/D	19	27 ± 13*	3.6 ± 2	234 ± 161*	244 ± 182	208 ± 173
I/D	42	24 ± 13	4 ± 2.3*	294 ± 238	291 ± 204	247 ± 165
I/I	22	18 ± 11*	2.8 ± 1.7*	376 ± 203*	331 ± 218	274 ± 167
P value		0.02	0.02	0.03	NS	NS

Data presented as the mean ± standard error of the mean
PAI-1 Plasminogen activator inhibitor type-1, A Adenosine, G Guanine, ACE Angiotensin converting enzyme, I Insertion, D Deletion, n Number of patients, t-PA Tissue plasminogen activator, 0 h Immediately after surgery, 6, 24 h 6 and 24 h postoperatively. *P < 0.05 between genotypes

ISSN: 1471-2253