Table 3 Drugs and drug combinations most frequently involved in DDIs
Detecting CDSS (interactions in total) | Drug combinations | % | Drugs | % | |
|---|---|---|---|---|---|
AU (261) | Severe (3.8 %) | ASS-Ibuprofen | 80 | ASS | 40 |
Melperone-Ropinirole | 10 | Ibuprofen | 40 | ||
Levofloxacin-Amitriptyline | 10 | Levofloxacin | 5 | ||
Amitriptyline | 5 | ||||
Ropinirole | 5 | ||||
Melperone | 5 | ||||
Severe/Considerable (36.3 %) | Tramadol-Pregabalin | 3.1 | Pregablin | 8.4 | |
Amitriptyline-Tramadol | 3.1 | Ibuprofen | 7.8 | ||
Ibuprofen-Enalapril | 3.1 | Amitriptyline | 7.3 | ||
Pregabalin-Morphine | 3.1 | ||||
Significant (rare) (37.9 %) | Ramipril-HCT | 3 | ASS | 9.6 | |
Pantoprazole-ASS | 3 | HCT | 8.5 | ||
ASS-Olmesartan | 3 | Ibuprofen | 6 | ||
Metformin-ASS | 3 | ||||
Slight (16.4 %) | ASS-Amlodipine | 14.9 | ASS | 32.5 | |
ASS-Ramipril | 11.6 | Amlodipine | 8.1 | ||
ASS-Bisoprolol | 9.3 | Thyroxine | 8.1 | ||
ASS-Metoprolol | 9.3 | ||||
Not relevant (5.3 %) | Pantoprazole-Diclofenac | 21.4 | Pantoprazole | 21.4 | |
Pantoprazole-Duloxetine | 21.4 | Diclofenac | 10.7 | ||
Carbamazepine | 10.7 | ||||
Duloxetine | 10.7 | ||||
MS (178) | Severe (6.7 %) | ASS-Ibuprofen | 50 | ASS | 25 |
Telmisartan-Ramipril | 16.6 | Ibuprofen | 25 | ||
Significant (75.2 %) | ASS-Ibuprofen | 8.2 | ASS | 17.5 | |
Ibuprofen-Diclofenac | 7.5 | Ibuprofen | 16.8 | ||
Minor Significant (17.9 %) | ASS-Ibuprofen | 18.7 | Ibuprofen | 21.8 | |
Diclofenac-Ibuprofen | 15.6 | ASS | 18.7 | ||
AID (170) | Severe (11.7 %) | Ibuprofen-ASS | 40 | Ibuprofen | 25 |
Amitriptyline-Tramadol | 15 | ASS | 20 | ||
Trimipramine-Tramadol | 10 | Tramadol | 12.5 | ||
Potentially clinically relevant (42.9 %) | Ramipril-ASS | 6.8 | ASS | 11.6 | |
HCT-Ramipril | 4.1 | Ramipril | 8.9 | ||
Enalapril-Ibuprofen | 4.1 | HCT | 8.2 | ||
Pregabalin-Oxycodone | 4.1 | ||||