From: Cytidine-5-diphosphocholine reduces microvascular permeability during experimental endotoxemia
Time after induction of endotoxemia | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
0 min | 60 min | 120 min | ||||||||||
Mean arterial pressure [mmHg] | Median | IQR (Q1-Q3) | * | Median | IQR (Q1-Q3) | *1 | #2 | Median | IQR (Q1-Q3) | * | # | |
NaCI | (i) | 117 | 100-126 | ns3 | 131 | 125-137 | 0.0037 | ns | 133 | 118-145 | 0.0386 | ns |
CDP-choline prior to NaCI | (ii) | 108 | 101-118 | ns | 117 | 93-132 | ns | ns | 133 | 104-139 | ns | ns |
CDP-choline prior to LPS | (iii) | 105 | 97-123 | ns | 105 | 101-114 | ns | ns | 113 | 60-117 | ns | ns |
CDP-choline after LPS | (iv) | 106 | 94-120 | ns | 105 | 89-120 | ns | ns | 114 | 100-122 | ns | ns |
LPS | (v) | 103 | 89-109 | 99 | 89-104 | ns | 106 | 97-112 | ns | |||
Heart rate [min−1] | Median | IQR (Q1-Q3) | * | Median | IQR (Q1-Q3) | * | # | Median | IQR (Q1-Q3) | * | # | |
NaCI | (i) | 322 | 317-344 | ns | 371 | 332-403 | 0.0037 | 0.0002 | 395 | 326-441 | 0.0327 | <0.0001 |
CDP-choline prior to NaCI | (ii) | 358 | 338-411 | ns | 408 | 400-473 | ns | 0.0313 | 433 | 428-470 | ns | 0.0313 |
CDP-choline prior to LPS | (iii) | 375 | 351-456 | ns | 475 | 447-566 | ns | 0.0156 | 449 | 441-493 | ns | 0.0313 |
CDP-choline after LPS | (iv) | 353 | 287-380 | ns | 381 | 326-432 | ns | 0.0117 | 445 | 358-476 | ns | 0.0039 |
LPS | (v) | 340 | 320-353 | 410 | 391-436 | 0.0078 | 491 | 435-516 | 0.0078 | |||
Venular wall shear rate [s−1] | Median | IQR (Q1-Q3) | * | Median | IQR (Q1-Q3) | * | # | Median | IQR (Q1-Q3) | * | # | |
NaCI | (i) | 400 | 352-575 | ns | 505 | 413-642 | ns | 0.0006 | 444 | 368-573 | ns | ns |
CDP-choline prior to NaCI | (ii) | 550 | 427-653 | ns | 420 | 356-614 | ns | ns | 302 | 230-631 | ns | 0.0395 |
CDP-choline prior to LPS | (iii) | 436 | 367-567 | ns | 362 | 274-553 | ns | 0.0229 | 311 | 120-497 | ns | 0.0009 |
CDP-choline after LPS | (iv) | 503 | 407-582 | ns | 397 | 321-505 | ns | 0.0301 | 443 | 281-590 | ns | 0.0254 |
LPS | (v) | 499 | 405-622 | 378 | 251-523 | ns | 348 | 285-493 | 0.0026 |