Cytidine-5-diphosphocholine reduces microvascular permeability during experimental endotoxemia

BMC Anesthesiology

Table 3 Summarized macro- and microhemodynamic parameters

		Time after induction of endotoxemia
		0 min			60 min				120 min
Mean arterial pressure [mmHg]		Median	IQR (Q1-Q3)	*	Median	IQR (Q1-Q3)	*¹	#²	Median	IQR (Q1-Q3)	*	#
NaCI	(i)	117	100-126	ns³	131	125-137	0.0037	ns	133	118-145	0.0386	ns
CDP-choline prior to NaCI	(ii)	108	101-118	ns	117	93-132	ns	ns	133	104-139	ns	ns
CDP-choline prior to LPS	(iii)	105	97-123	ns	105	101-114	ns	ns	113	60-117	ns	ns
CDP-choline after LPS	(iv)	106	94-120	ns	105	89-120	ns	ns	114	100-122	ns	ns
LPS	(v)	103	89-109		99	89-104		ns	106	97-112		ns
Heart rate [min⁻¹]		Median	IQR (Q1-Q3)	*	Median	IQR (Q1-Q3)	*	#	Median	IQR (Q1-Q3)	*	#
NaCI	(i)	322	317-344	ns	371	332-403	0.0037	0.0002	395	326-441	0.0327	<0.0001
CDP-choline prior to NaCI	(ii)	358	338-411	ns	408	400-473	ns	0.0313	433	428-470	ns	0.0313
CDP-choline prior to LPS	(iii)	375	351-456	ns	475	447-566	ns	0.0156	449	441-493	ns	0.0313
CDP-choline after LPS	(iv)	353	287-380	ns	381	326-432	ns	0.0117	445	358-476	ns	0.0039
LPS	(v)	340	320-353		410	391-436		0.0078	491	435-516		0.0078
Venular wall shear rate [s⁻¹]		Median	IQR (Q1-Q3)	*	Median	IQR (Q1-Q3)	*	#	Median	IQR (Q1-Q3)	*	#
NaCI	(i)	400	352-575	ns	505	413-642	ns	0.0006	444	368-573	ns	ns
CDP-choline prior to NaCI	(ii)	550	427-653	ns	420	356-614	ns	ns	302	230-631	ns	0.0395
CDP-choline prior to LPS	(iii)	436	367-567	ns	362	274-553	ns	0.0229	311	120-497	ns	0.0009
CDP-choline after LPS	(iv)	503	407-582	ns	397	321-505	ns	0.0301	443	281-590	ns	0.0254
LPS	(v)	499	405-622		378	251-523		ns	348	285-493		0.0026

ISSN: 1471-2253