From: Cytidine-5-diphosphocholine reduces microvascular permeability during experimental endotoxemia
Time after induction of endotoxemia | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
0 min | 60 min | 120 min | ||||||||||
Adherent leukocytes [cells/ mm2] | Median | IQR (Q1-Q3) | * | Median | IQR (Q1-Q3) | *1 | #2 | Median | IQR (Q1-Q3) | * | # | |
NaCI | (i) | 140 | 59-218 | ns3 | 172 | 85-201 | 0.0139 | ns | 136 | 74-216 | <0.0001 | ns |
CDP-choline prior to NaCI | (ii) | 206 | 75-268 | ns | 204 | 108-251 | ns | ns | 220 | 147-337 | 0.015 | ns |
CDP-choline prior to LPS | (iii) | 204 | 165-250 | ns | 243 | 169-375 | ns | 0.0175 | 322 | 234-423 | ns | <0.0001 |
CDP-choline after LPS | (iv) | 239 | 128-271 | ns | 305 | 232-351 | ns | <0.0001 | 342 | 226-418 | ns | 0.0003 |
LPS | (v) | 193 | 118-280 | 267 | 193-358 | 0.0038 | 403 | 224-562 | <0.0001 |