From: Cytidine-5-diphosphocholine reduces microvascular permeability during experimental endotoxemia
Time after induction of endotoxemia | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
0 min | 60 min | 120 min | ||||||||||
Macromolecular leakage [arbitrary units] | Median | IQR (Q1-Q3) | * | Median | IQR (Q1-Q3) | *1 | #2 | Median | IQR (Q1-Q3) | * | # | |
NaCI | (i) | 0.075 | 0.05-0.09 | ns3 | 0.15 | 0.11-0.2 | <0.0001 | 0.0002 | 0.22 | 0.14-0.29 | <0.0001 | <0.0001 |
CDP-choline prior to NaCI | (ii) | 0.067 | 0.05-0.09 | ns | 0.11 | 0.07-0.21 | <0.0001 | 0.0054 | 0.21 | 0.08-0.36 | <0.0001 | 0.0008 |
CDP-choline prior to LPS | (iii) | 0.095 | 0.07-0.12 | ns | 0.24 | 0.12-0.42 | 0.0141 | <0.0001 | 0.35 | 0.15-0.51 | 0.0019 | <0.0001 |
CDP-choline after LPS | (iv) | 0.095 | 0.06-0.12 | ns | 0.27 | 0.18-0.47 | ns | <0.0001 | 0.34 | 0.25-0.49 | 0.0022 | <0.0001 |
LPS | (v) | 0.099 | 0.07-0.11 | 0.48 | 0.34-0.63 | <0.0001 | 0.6 | 0.51-0.71 | <0.0001 |