Tracheostomy in intensive care unit patients can be performed without bleeding complications in case of normal thromboelastometry results (EXTEM CT) despite increased PT-INR: a prospective pilot study

Table 1 ROTEM-EXTEM and laboratory coagulation parameters in examined patients

EXTEM parameters	INR 1.21-1.29 (mean ± SD)	INR ≥ 1.3 (mean ± SD)	Nonsepsis (mean ± SD)	Sepsis (mean ± SD)
CT (seconds)	58.60 ± 14.01	60.79 ± 7.58 ^ns	58.75 ± 10.42	61.92 ± 7.29 ^ns
CFT (seconds)	50.40 ± 21.41	67.05 ± 24.98 ^ns	71.17 ± 27.75	56.00 ± 19.8 ^ns
α angle (degrees)	80.60 ± 4.04	76.79 ± 4.67 ^ns	76.50 ± 5.27	78.67 ± 4.8 ^ns
A10 (mm)	69.00 ± 9.67	65.16 ± 8.02 ^ns	62.75 ± 8.98	69.17 ± 6.44 ^p=0.056
MCF (mm)	73.2 ± 8.17	70.47 ± 6.02 ^ns	68.33 ± 6.91	73.75 ± 4.75 *
LI30 (%)	99.60 ± 0.55	99.63 ± 0.59 ^ns	99.58 ± 0.67	99.67 ± 0.49 ^ns
LI60 (%)	94.00 ± 4.12	96.47 ± 3.47 ^ns	93.50 ± 3.56	98.42 ± 1.51 ***
ML (%)	9.00 ± 5.61	6.21 ± 4.93 ^ns	9.67 ± 4.89	3.92 ± 3.48 **
Laboratory parameters
Fibrinogen g/L	4.57 ± 0.88	4.73 ± 6.62 ^ns	4.72 ± 0.53	4.68 ± 0.79 ^ns
Platelets(x10⁹/L)	209.4 ± 132.5	160.1 ± 77.18 ^ns	164.8 ± 101.1	175.9 ± 81.99 ^ns

CT – coagulation time, time from the start of the sample run to the first detectable clot formation (amplitude =2 mm); CFT – clot formation time, time from CT to the clot amplitude of 20 mm (to specify the kinetics of the clot development); α angle, angle between the trace and the x-axis; A10 clot firmness (in mm amplitude) at the respective, time point after CT
MCF- maximum clot firmness; LI30 and LI60 - Lysis Index at time 30 and 60 min after CT; ML - maximum lysis during whole measuring time of (90 min)
Normal values for ROTEM: EXTEM – CT 38–79 s, CFT 34–159 s, α angle 63-83°, MCF 50–72 mm, LI30 0-7 %, LI60 0-15 %; Fibrinogen- 1.8-4.2 g/L, Platelets count – 150-400x10⁹/L
ns - means nonsignificant difference between two groups p > 0.05 * means significant difference between two groups p < 0.05 ** means significant difference between two groups p < 0.01 *** means significant difference between 2 groups p < 0.001

ISSN: 1471-2253