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Table 1 Overview of early-goal directed protocols and high transfusion triggers (selection)

From: Should we restrict erythrocyte transfusion in early goal directed protocols?

Study

Field of interest

RBC transfusion trigger

Rivers et al. [1]

Severe sepsis and septic shock

Hct < 30%, if ScvO2 < 70%

Lobo et al. [10]

Major non-cardiac surgery

Hct < 30%, if PAOP < 16 mm Hg

Donati et al. [11]

Major abdominal surgery

Hb < 10 g/dl, if CVP < 10 mm Hg

Smetkin et al. [12]

Cardiac surgery

Hb < 8 g/dl, if ScvO2 < 60%

ProMISe Investigators [13]

Severe sepsis and septic shock

Hb < 10 g/dl, if ScvO2 < 70%

ProCESS Investigators [4]

Septic shock

Hct < 30%, if ScvO2 < 70%

ARISE Investigators [5]

Septic shock

Hct < 30%, if ScvO2 < 70%

  1. Hct indicates hematocrit; Hb, hemoglobin; ScvO2, central venous oxygen saturation; CVP, central venous pressure; PAOP, pulmonary artery occlusion pressure.