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Table 2 Sensitivity and specificity (95% confidence intervals) to detect reduced or augmented endogenous creatinine clearance

From: Estimation of creatinine clearance using plasma creatinine or cystatin C: a secondary analysis of two pharmacokinetic studies in surgical ICU patients

 

CLCR<60 mL/min/1.73 m2

CLCR>130 mL/min/1.73 m2

 

sensitivity

specificity

sensitivity

specificity

eCLCG

0.55 (0.39-0.70)

0.95 (0.86-0.99)

0.69 (0.41-0.89)**

0.81 (0.71-0.89)***

eCLCKD-EPI

0.55 (0.39-0.70)

0.97 (0.88-1.0)

0.25 (0.073-0.52)

0.96 (0.90-0.99)

eCLHoek

0.83 (0.69-0.93)*

0.91 (0.81-0.97)

0.38 (0.15-0.65)

0.96 (0.90-0.99)

  1. CLCR: measured endogenous creatinine clearance; eCLCG, eCLCKD-EPI, eCLHoek: estimated clearance by the Cockcroft-Gault, CKD-EPI or Hoek formula.
  2. *different from eCLCG and eCLCKD-EPI (p < 0.01).
  3. **different from eCLCKD-EPI (p < 0.05).
  4. ***different from eCLCKD-EPI and eCLHoek (p < 0.01).
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BMC Anesthesiology

ISSN: 1471-2253

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