Table 5 Baseline measurements and treatment effects on heart rate, pulse pressure, central venous pressure, patient temperature, net fluid balance, pH, PaO 2 /FiO 2 ratio, lactate, bilirubin, INR and APTT
Effect size (SE) | P-value | |
|---|---|---|
Heart rate | ||
Treatment effect (Pre v P1 v P12)† | 0.002 | |
P1-Pre | 5.15 (1.88) | 0.006 |
P12-Pre | −1.12 (1.97) | 0.568 |
P12-P1 | −6.28 (1.97) | 0.001 |
Baseline lactate | 1.4 (0.39) | <0.001 |
Pulse pressure (mmHg) | ||
Treatment effect (Pre v P1 v P12) | 0.456 | |
P1-Pre | 0.55 (1.88) | 0.772 |
P12-Pre | 2.40 (1.98) | 0.226 |
P12-P1 | 1.85 (1.98) | 0.350 |
Baseline bilirubin | 0.05 (0.01) | <0.001 |
Central venous pressure (mmHg) | ||
Treatment effect (Pre v P1 v P12) | <0.001 | |
P1-Pre | −1.00 (0.69) | 0.146 |
P12-Pre | −2.96 (0.73) | <0.001 |
P12-P1 | −1.96 (0.73) | 0.007 |
Baseline bilirubin | 0.01 (0.004) | 0.007 |
Temperature (Celsius) | ||
Treatment effect (Pre v P1 v P12) | 0.011 | |
P1-Pre | 0.41 (0.16) | 0.013 |
P12-Pre | −0.04 (0.17) | 0.792 |
P12-P1 | −0.45 (0.17) | 0.008 |
Fluid balance (ml) | ||
Treatment effect (Pre v P1 v P12) | 0.021 | |
P1-Pre | 34.1 (254.1) | 0.893 |
P12-Pre | −627.5 (264.9) | 0.018 |
P12-P1 | −661.6 (564.9) | 0.013 |
pH | ||
Treatment effect (Pre v P1 v P12) | 0.053 | |
P1-Pre | 0.03 (0.02) | 0.122 |
P12-Pre | 0.04 (0.02) | 0.025 |
P12-P1 | 0.01 (0.02) | 0.798 |
PaO 2 /FiO 2 | ||
Treatment effect (Pre v P1 v P12) | 0.073 | |
P1-Pre | −0.05 (0.21) | 0.801 |
P12-Pre | −0.39 (0.18) | 0.029 |
P12-P1 | −0.34 (0.22) | 0.118 |
RRT at baseline | −1.40 (0.49) | 0.005 |
Lactate (mmol/L) | ||
Treatment effect (Pre v P1 v P12) | 0.588 | |
P1-Pre | 0.25 (0.57) | 0.664 |
P12-Pre | −0.35 (0.46) | 0.449 |
P12-P1 | −0.60 (0.62) | 0.331 |
Bilirubin (µmol/L) | ||
Treatment effect (Pre v P1 v P12) | 0.026 | |
P1-Pre | −44.4 (17.3) | 0.010 |
P12-Pre | 5.33 (11.7) | 0.649 |
P12-P1 | 49.7 (19.3) | 0.010 |
INR | ||
Treatment effect (Pre v P1 v P12) | 0.025 | |
P1-Pre | −1.55 (0.63) | 0.014 |
P12-Pre | −0.90 (0.55) | 0.103 |
P12-P1 | 0.65 (0.75) | 0.383 |
APTT (s) | ||
Treatment effect (Pre v P1 v P12) | 0.421 | |
P1-Pre | −1.57 (4.12) | 0.703 |
P12-Pre | −4.53 (3.45) | 0.189 |
P12-P1 | −2.97 (4.41) | 0.501 |