Table 2 Physiologic variables during IV JM-1232(-) application (n = 9)

MAP (mmHg)

82 ± 15

92 ± 13

94 ± 91

87 ± 12

83 ± 12*

78 ± 12*

82 ± 11*

90 ± 10

HR (bpm)

279 ± 15

273 ± 15

277 ± 21

260 ± 13

249 ± 27

239 ± 22*

272 ± 17

277 ± 16

RT(°C)

39.6 ± 0.8

39.6 ± 0.8

39.6 ± 0.7

39.6 ± 0.7

39.6 ± 0.7

39.6 ± 0.7

39.5 ± 0.6

39.6 ± 0.6

pH

7.44 ± 0.02

7.42 ± 0.03

7.41 ± 0.03

7.40 ± 0.03

7.40 ± 0.03

7.42 ± 0.03

7.39 ± 0.03

7.39 ± 0.03

PaCO2 (mmHg)

38 ± 3

40 ± 2

40 ± 2

41 ± 4

40 ± 3

40 ± 2

40 ± 2

40 ± 1

PaO2 (mmHg)

441 ± 38

455 ± 25

458 ± 27

456 ± 37

455 ± 33

451 ± 25

453 ± 28

454 ± 27

Na⁺ (mEq/L)

141 ± 1

141 ± 1

141 ± 1

142 ± 1

141 ± 1

142 ± 1

142 ± 2

142 ± 1

K⁺ (mEq/L)

3.8 ± 0.2

3.8 ± 0.2

3.8 ± 0.3

3.7 ± 0.2

3.7 ± 0.2

3.6 ± 0.1

3.7 ± 0.1

3.8 ± 0.2

BS(mg/dl)

123 ± 8*

122 ± 7*

128 ± 13

140 ± 12*

144 ± 13*

155 ± 19*

160 ± 19*

158 ± 20*

BE

2.3 ± 3.1

2.1 ± 2.7

2.2 ± 2.4

1.9 ± 2.6

1.9 ± 2.2

0.7 ± 2.6*

0.0 ± 2.8*

0.3 ± 2.1*

Lactate (mmol/L)

2.8 ± 0.7

2.9 ± 0.5

2.8 ± 0.4

3.4 ± 0.6*

4.2 ± 1.0*

5.0 ± 1.5*

5.4 ± 1.5*

5.2 ± 1.2*