Figure 2

The effects of intravenous administratin of JM-1232(-) on cerebral pial arteriolar (A) and venular (B) diameters. (n = 9) Values are means ± SDs. Data are percent change in diameters compared with control (just before JM-1232(-) infusion). After discontinuation of sevoflurane, arteriolar and venular diameters constricted significantly. After intravenous administration of JM-1232(-), cerebral pial arteriolar constriction was induced at the time between 5 min and 60 min (A) and venular constriction was induced between 10 min and 60 min (B). After discontinuation of JM-1232(-), cerebral pial arteriolar (A) and venular (B) constriction were attenuated. S = sevoflurane. * P < 0.05, † P < 0.01, compared with control.