Table 1 The pharmacokinetic parameters for the three compartmental model with cardiac output (CO, L.min-1) and weight (WT, kg) as covariates (tested for parsimony).

   V1 = 5.65 + 0.020(WT-70) + 0.68(CO-5)

   V2 = 8.35 + 0.15(WT-70) - 0.49(CO-5)

   V3 = 134.09 + 1.91(WT-70)

   CL1 = 1.23 + 0.050(CO-5)

   CL2 = 2.57 + 0.010(WT-70) + 0.47(CO-5)

   CL3 = 0.87 + 0.17(CO-5)

Isoflurane

   V1 = 4.21 + 0.020(WT-70) + 0.39(CO-5)

   V2 = 3.16 + 0.065(WT-70) - 0.31(CO-5)

   V3 = 61.40 + 0.87(WT-70)

   CL1 = 1.12 + 0.024(CO-5)

   CL2 = 1.05 + 0.0037(WT-70) + 0.17(CO-5)

   CL3 = 0.46 + 0.092(CO-5)

Sevoflurane

   V1 = 3.33 + 0.018(WT-70) + 0.21(CO-5)

   V2 = 1.51 + 0.033(WT-70) - 0.18(CO-5)

   V3 = 33.69 + 0.47(WT-70)

   CL1 = 1.05 + 0.011(CO-5)

   CL2 = 0.37 + 0.0034(WT-70) + 0.053(CO-5)

   CL3 = 0.23 + 0.046(CO-5)

Desflurane

   V1 = 2.94 + 0.017(WT-70) + 0.14(CO-5)

   V2 = 1.56 + 0.030(WT-70) - 0.14(CO-5)

   V3 = 14.08 + 0.19(WT-70)

   CL1 = 1.03 + 0.0066(CO-5)

   CL2 = 0.25 + 0.0022(WT-70) + 0.036(CO-5)

   CL3 = 0.14 + 0.029(CO-5)