The effect of valdecoxib (40 mg, PO) and placebo on the skin area of allodynia (panel A) and mechanical hyperalgesia (panel B) after skin heat/capsaicin sensitization performed 120 min after study drug or placebo administration. The areas of allodynia (response to paint brush stimulation) and mechanical hyperalgesia (response to von Frey hair stimulation) are expressed as mean ± SD in cm2. Time scale indicates the time (in min) after study drug or placebo administration and when the pain measurements were performed. Black columns represent valdecoxib administration; white columns represent placebo administration. The results were compared using the Wilcoxon signed ranks test.