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Table 3 Halothane-induced contractures with and without cyclopiazonic acid 25 μM (CPA) pre-incubation; median and quartile; * p < 0.05 for differences between IVCT and CPA-IVCT.

From: Inhibition of sarcoplasmic Ca2+-ATPase increases caffeine- and halothane-induced contractures in muscle bundles of malignant hyperthermia susceptible and healthy individuals

Halothane [mM]

0.11

0.22

0.44

0.66

MHS [mN]

5 (2 – 6)

14 (13 – 20)

20 (16 – 26)

19 (11 – 24)

MHS CPA [mN]

40 (26 – 58)*

52 (29 – 76)*

59 (33 – 73)*

48 (30 – 57)*

MHEh [mN]

0 (0 – 0)

(0 – 1)

4 (2 – 4)

3 (2 – 4)

MHEh CPA [mN]

7 (1 – 11)*

25 (13 – 39)*

45 (24 – 55)*

45 (25 – 48)*

MHN [mN]

1 (0 – 2)

1 (0 – 1)

1 (1 – 1)

1 (0 – 1)

MHN CPA [mN]

1 (0 – 3)

2 (0 – 25)

16 (4 – 34)*

20 (9–31)*